{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:16:42Z","timestamp":1787019402894,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T00:00:00Z","timestamp":1470960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Limited data are available on risk factors associated with lichen sclerosus and no data are available on gender differences in genital lichen sclerosus (\n                      <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This multicentre study aimed at identifying potential risk factors for\n                      <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>\n                      , through data collection from a large, mixed\u2010sex sample of patients comparing gender\u2010related differences in relation to data from the general population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This was a cross\u2010sectional study on 729 subjects (53.8% females, 46.2% males) affected with\n                      <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>\n                      , consecutively observed within a network of 15 Italian dermatology units. The following information was collected: demographic data, anthropometric measures, comorbidities, family history of\n                      <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n                      , clinical features and symptoms related to\n                      <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overweight and obesity, blood hypertension, hypothyroidism and an educational attainment equal or above upper secondary school level were more frequent among the study patients than among the general Italian population. Moreover, a family history of\n                      <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>\n                      was reported more frequently than expected among\n                      <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>\n                      patients. These factors were similar in males and females. The disease tended to occur later in females than in males.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Our findings suggest that metabolic factors, and possibly a sedentary lifestyle, may play a role in\n                      <jats:styled-content style=\"fixed-case\">GLS<\/jats:styled-content>\n                      pathogenesis in genetically predisposed patients, and that risk profile is similar in males and females despite some difference in the onset of symptoms.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.13867","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T04:49:57Z","timestamp":1470977397000},"page":"699-704","source":"Crossref","is-referenced-by-count":59,"title":["New insights into potential risk factors and associations in genital lichen sclerosus: Data from a multicentre Italian study on 729 consecutive cases"],"prefix":"10.1111","volume":"31","author":[{"given":"A.","family":"Virgili","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Mediche Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Borghi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cazzaniga","sequence":"additional","affiliation":[{"name":"Centro Studi GISED \u2013 FROM Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Di Landro","sequence":"additional","affiliation":[{"name":"Centro Studi GISED \u2013 FROM Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Naldi","sequence":"additional","affiliation":[{"name":"Centro Studi GISED \u2013 FROM Bergamo Italy"},{"name":"UO di Dermatologia Azienda Ospedaliera papa Giovanni XXIII Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Minghetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Verrone","sequence":"additional","affiliation":[{"name":"Dermosifilopatia 2 Azienda Ospedaliera Citt\u00e0 della Salute e della Scienza di Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Stroppiana","sequence":"additional","affiliation":[{"name":"Dermosifilopatia 2 Azienda Ospedaliera Citt\u00e0 della Salute e della Scienza di Torino Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Caproni","sequence":"additional","affiliation":[{"name":"Malattie Rare Dermatologiche e Immunopatologia Cutanea U.O. 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