{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:14:10Z","timestamp":1792030450948,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["444547\/2014\u20102"],"award-info":[{"award-number":["444547\/2014\u20102"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Erythroderma is a clinical skin syndrome shared by patients with cutaneous disorders of distinct aetiologies as a result of the combined actions of chemokines, adhesion molecules, and cytokines, such as vascular endothelial growth factor (\n VEGF<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To evaluate the profile of serum levels of\n VEGF<\/jats:styled-content>\n and soluble vascular endothelial growth factor receptor 1 (\n sVEGFR<\/jats:styled-content>\n \u20101) in pemphigus foliaceus (\n PF<\/jats:styled-content>\n ) patients with erythroderma.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a retrospective study, which included (i) a chart review of all\n PF<\/jats:styled-content>\n patients from the Autoimmune Blistering Clinic, University of Sao Paulo, Brazil, from January 1991 to December 2014, together with an evaluation of demographic variables, hospitalization duration and complications and (ii) analysis of the circulating\n VEGF<\/jats:styled-content>\n and\n sVEGFR<\/jats:styled-content>\n \u20101 levels in\n PF<\/jats:styled-content>\n patients with erythroderma by\n ELISA<\/jats:styled-content>\n . The controls included patients with pemphigus vulgaris or psoriasis.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We observed higher serum\n VEGF<\/jats:styled-content>\n levels in\n PF<\/jats:styled-content>\n patients during erythroderma than during the non\u2010erythrodermic phase.\n PF<\/jats:styled-content>\n patients showed increased serum levels of\n sVEGFR<\/jats:styled-content>\n \u20101 during the erythrodermic phase in comparison to controls. Interestingly, the\n sVEGFR<\/jats:styled-content>\n \u20101 and antidesmoglein\u20101 levels were positively correlated during the non\u2010erythrodermic period.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Erythroderma, which represents one clinical form of\n PF<\/jats:styled-content>\n , implies more severe outcomes. The circulating levels of\n VEGF<\/jats:styled-content>\n , a potent endothelial activator, are increased in\n PF<\/jats:styled-content>\n patients with erythroderma; this result suggests the contribution of the blood vessel endothelium to the pathogenesis of this clinical syndrome. Interestingly, our findings showed a positive correlation between the\n sVEGFR<\/jats:styled-content>\n \u20101 and antidesmoglein\u20101 antibody levels, indicating a suppressive response to\n VEGF<\/jats:styled-content>\n augmentation during the erythrodermic phase of\n PF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.13905","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T04:22:52Z","timestamp":1470889372000},"page":"333-336","source":"Crossref","is-referenced-by-count":12,"title":["Increased serum levels of vascular endothelial growth factor in pemphigus foliaceus patients with erythroderma"],"prefix":"10.1111","volume":"31","author":[{"given":"D.","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Dermatology University of S\u00e3o Paulo Medical School S\u00e3o Paulo 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