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In fact, <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s' ability to promote wound healing through its paracrine function and pro\u2010angiogenic properties have generated increasing interest for treating acute and chronic wounds. There is also great interest in utilizing <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s' immunological characteristics for therapeutic use especially for patients with debilitating systemic autoimmune and inflammatory skin conditions who have failed other therapies. Its role in aesthetics has also been explored with clinical data showing improvement of acne scars and wrinkles from photoaging. Clinical trials are underway investigating the safety and efficacy of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s in the treatment of different skin conditions such as acute burns, diabetic and venous stasis ulcers, epidermolysis bullosa and systemic sclerosis, among others. We anticipate that as our understanding of the characteristics and function of <jats:styled-content style=\"fixed-case\">MSC<\/jats:styled-content>s grow, so will its role in cell\u2010based treatments of dermatological conditions.<\/jats:p>","DOI":"10.1111\/jdv.13934","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T07:26:47Z","timestamp":1471937207000},"page":"414-423","source":"Crossref","is-referenced-by-count":43,"title":["Mesenchymal stromal cells: properties and role in management of cutaneous diseases"],"prefix":"10.1111","volume":"31","author":[{"given":"K.H.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Arkansas for Medical Sciences Little Rock AR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Blasco\u2010Morente","sequence":"additional","affiliation":[{"name":"Department of Dermatology Virgen de las Nieves University Hospital Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Cuende","sequence":"additional","affiliation":[{"name":"Andalusian Initiative for Advanced Therapies Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Arias\u2010Santiago","sequence":"additional","affiliation":[{"name":"Department of Dermatology Virgen de las Nieves University Hospital Granada Spain"},{"name":"Cell Production and Tissue Engineering Unit Virgen de las Nieves University Hospital Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.8.2396"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2014.10.004"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(91)90401-F"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-02-0105"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000000083"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1291"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1670"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0342"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0439"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2007.0154"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07492.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.022"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2005.11.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0197"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2657"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-013-9697-2"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020399"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.62"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700715"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63431-1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0080587"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.178962"},{"key":"e_1_2_7_25_1","first-page":"2581","article-title":"Mesenchymal stem cells are recruited into wounded skin and contribute to wound repair by transdifferentiation into multiple skin cell type","volume":"2008","author":"Sasaki M","year":"1950","journal-title":"J Immunol"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12335"},{"key":"e_1_2_7_27_1","first-page":"68","article-title":"Healing potential of mesenchymal stem cells cultured on a collagen\u2010based scaffold for skin regeneration","volume":"16","author":"Shokrgozar MA","year":"2012","journal-title":"Iran Biomed J"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0226"},{"key":"e_1_2_7_29_1","doi-asserted-by":"crossref","unstructured":"Pytlik Slanar Stehlik Matejkov.Production of Clinical Grade Mesenchymal Stromal Cells. 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