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Different therapeutic approaches to treat acute <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> are available. The aim of this European project was the elaboration of a consensus\u2010based guideline on the management of patients who present with <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>, considering different patient populations and different localizations. This interdisciplinary guideline aims at an improvement of the outcomes of the acute <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> management concerning disease duration, acute pain and quality of life of the affected patients and at a reduction in the incidence of postherpetic neuralgia (<jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>) and other complications. The guideline development followed a structured and pre\u2010defined process, considering the quality criteria for guidelines development as suggested by the <jats:styled-content style=\"fixed-case\">AGREE II<\/jats:styled-content> instrument. The steering group was responsible for the planning and the organization of the guideline development process (Division of Evidence\u2010Based Medicine, <jats:styled-content style=\"fixed-case\">dEBM<\/jats:styled-content>). The expert panel was nominated by virtue of clinical expertise and\/or scientific experience and included experts from the fields of dermatology, virology\/infectiology, ophthalmology, otolaryngology, neurology and anaesthesiology. Recommendations for clinical practice were formally consented during the consensus conference, explicitly considering different relevant aspects. The guideline was approved by the commissioning societies after an extensive internal and external review process. In this second part of the guideline, therapeutic interventions have been evaluated. The expert panel formally consented recommendations for the treatment of patients with <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> (antiviral medication, pain management, local therapy), considering various clinical situations. Users of the guideline must carefully check whether the recommendations are appropriate for the context of intended application. In the setting of an international guideline, it is generally important to consider different national approaches and legal circumstances with regard to the regulatory approval, availability and reimbursement of diagnostic and therapeutic interventions.<\/jats:p>","DOI":"10.1111\/jdv.13957","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T18:37:29Z","timestamp":1472668649000},"page":"20-29","source":"Crossref","is-referenced-by-count":159,"title":["European consensus\u2010based (S2k) Guideline on the Management of Herpes Zoster \u2013 guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), Part 2: Treatment"],"prefix":"10.1111","volume":"31","author":[{"given":"R.N.","family":"Werner","sequence":"first","affiliation":[{"name":"Department of Dermatology Venereology and Allergology Division of Evidence\u2010Based Medicine in Dermatology (dEBM) Charit\u00e9 \u2013 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