{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:23:27Z","timestamp":1788276207740,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T00:00:00Z","timestamp":1476057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Port\u2010wine stains (<jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>) are relatively common and often cause cosmetic and psychological concerns. The pulsed dye laser is currently the treatment of choice for <jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effectiveness of the pulsed sequential dual wavelength 595 and 1064 nm laser as first\u2010line treatment for <jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content> and to identify prognostic factors for treatment outcome in a retrospective series of 17 consecutive previously untreated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The response to treatment was evaluated 2 months after treatment utilizing comparative photographs and a standard physician global assessment (<jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content>) grading system. Furthermore, measurement of the normalized erythema index (<jats:styled-content style=\"fixed-case\">NEI<\/jats:styled-content>) reduction (\u0394<jats:styled-content style=\"fixed-case\">NEI<\/jats:styled-content>%) was carried out using an image analysis system. The subjective improvement was assessed using a patient's satisfaction questionnaire. Multiple linear regression models were finally used to identify factors associated with \u0394<jats:styled-content style=\"fixed-case\">NEI<\/jats:styled-content>% and patients\u2019 satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventeen patients, with <jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>, including 12 children were included. The average <jats:styled-content style=\"fixed-case\">PGA<\/jats:styled-content> assessment was 2.5 \u00b1 1.3 corresponding to an amelioration of 50% with a high intraclass correlation coefficient among the experts. The before\u2013after <jats:styled-content style=\"fixed-case\">NEI<\/jats:styled-content> showed a statistically significant mean reduction of 3.5 \u00b1 2.6 units, corresponding to a relative reduction of 31%. Questionnaires showed that the satisfaction was very good with an average score of 6.1 points on a scale ranging from \u221210 to 10 points. Multiple regression analysis revealed that location in the frontotemporal area was associated with a significant reduction in \u0394<jats:styled-content style=\"fixed-case\">NEI<\/jats:styled-content>% (38.4%; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.3, 72.6). Presence of <jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content> on the neck was associated with a lower patient satisfaction (\u22123.7 points; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22126.5, \u22120.9). There were no significant side\u2010effects, except for transient discomfort and purpura.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on the results obtained in the largest reported series so far, the pulsed sequential dual wavelength 595 and 1064 nm laser represents an effective and safe first\u2010line therapeutic option for the treatment of <jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.13975","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T18:57:17Z","timestamp":1474570637000},"page":"557-563","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of sporadic port\u2010wine stains: a retrospective review of 17 cases consecutively treated by pulsed sequential dual wavelength 595 and 1064 nm 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