{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:51:33Z","timestamp":1790553093083,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Cutaneous (\n CLP<\/jats:styled-content>\n ) and oral lichen planus (\n OLP<\/jats:styled-content>\n ) as the main subtypes of lichen planus (\n LP<\/jats:styled-content>\n ) present with different clinical manifestation and disease course, although their histopathologic features such as the band\u2010like lymphocyte infiltrate and keratinocyte apoptosis are similar. So far, the underlying cellular and molecular mechanisms remain poorly understood.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n The aim of this study was to characterize and compare the\n in situ<\/jats:italic>\n cellular infiltrates, cytokine expression profiles and apoptosis markers in\n CLP<\/jats:styled-content>\n and\n OLP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Using immunofluorescence staining and laser scanning microscopy, we evaluated the cellular infiltrate (\n CD<\/jats:styled-content>\n 1a,\n CD<\/jats:styled-content>\n 3,\n CD<\/jats:styled-content>\n 4,\n CD<\/jats:styled-content>\n 8,\n CD<\/jats:styled-content>\n 21,\n CD<\/jats:styled-content>\n 57,\n CD<\/jats:styled-content>\n 123), cytokine expression (interleukin (\n IL<\/jats:styled-content>\n )\u20101,\n IL<\/jats:styled-content>\n \u20106,\n IL<\/jats:styled-content>\n \u20109,\n IL<\/jats:styled-content>\n \u201010,\n IL<\/jats:styled-content>\n \u201017,\n IL<\/jats:styled-content>\n \u201022,\n IL<\/jats:styled-content>\n \u201023, tumour necrosis factor\u2010\u03b1, transforming growth factor\u2010\u03b2, interferon (\n IFN<\/jats:styled-content>\n )\u2010\u03b3), and apoptosis markers (Fas, Fas ligand, cleaved caspase\u20103,\n TUNEL<\/jats:styled-content>\n ) of 21 anonymized biopsy specimens of\n LP<\/jats:styled-content>\n (11\n CLP<\/jats:styled-content>\n , 10\n OLP<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Among infiltrating cells mainly T cells and natural killer (\n NK<\/jats:styled-content>\n ) cells as well as plasmacytoid dendritic cells (\n DC<\/jats:styled-content>\n ) were observed. A predominance of\n CD<\/jats:styled-content>\n 8+ T cells was noted in\n OLP<\/jats:styled-content>\n . In both\n CLP<\/jats:styled-content>\n and\n OLP<\/jats:styled-content>\n , T helper (Th)1, Th9, Th17, and Th22\u2010type cytokines were expressed. The expression of\n IL<\/jats:styled-content>\n \u20109,\n IFN<\/jats:styled-content>\n \u2010\u03b3 and\n IL<\/jats:styled-content>\n \u201022 was higher in\n CLP<\/jats:styled-content>\n compared to that of\n OLP<\/jats:styled-content>\n (\n P<\/jats:italic>\n = 0.0165;\n P<\/jats:italic>\n = 0.0016;\n P<\/jats:italic>\n = 0.052 respectively). Expression of Fas and Fas ligand as well as cleaved caspase\u20103\u2010positive cells was observed in the epithelium of all\n LP<\/jats:styled-content>\n samples.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The cell and cytokine patterns of\n CLP<\/jats:styled-content>\n and\n OLP<\/jats:styled-content>\n were partially distinct and generally resembled those reported for autoimmune diseases. The presence of\n CD<\/jats:styled-content>\n 8+ and\n NK<\/jats:styled-content>\n cells as well as Fas\/Fas ligand expression suggested that various pathways involved in keratinocyte apoptosis are relevant for\n LP<\/jats:styled-content>\n . These results might help to establish targeted therapies for\n LP<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.13989","type":"journal-article","created":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T08:36:39Z","timestamp":1475829399000},"page":"880-886","source":"Crossref","is-referenced-by-count":32,"title":["Distinct interferon\u2010gamma and interleukin\u20109 expression in cutaneous and oral lichen planus"],"prefix":"10.1111","volume":"31","author":[{"given":"B.","family":"Weber","sequence":"first","affiliation":[{"name":"Department of Dermatology Inselspital, Bern University Hospital University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Schlapbach","sequence":"additional","affiliation":[{"name":"Department of Dermatology Inselspital, Bern University Hospital University of Bern Bern 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