{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T18:09:51Z","timestamp":1713550191361},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T00:00:00Z","timestamp":1483920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006442","name":"Det Sundhedsvidenskabelige Fakultet, K\u00f8benhavns Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006442","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lichen planus (<jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>) is a chronic inflammatory disease of unknown aetiology affecting the skin and oral mucosa. Oral lichenoid lesions (<jats:styled-content style=\"fixed-case\">OLL<\/jats:styled-content>s), like oral contact reactions, may resemble oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) both clinically and histopathologically. As <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">OLL<\/jats:styled-content> are hyperkeratotic diseases and filaggrin is essential to keratinization, the distribution of filaggrin may be altered in these lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OLL<\/jats:styled-content> have (i) altered distribution of filaggrin in the oral mucosa; (ii) a higher incidence of mutations in the filaggrin gene (<jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>); (iii) active dermatoses, apart from cutaneous <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content>, than healthy controls; and (iv) patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OLL<\/jats:styled-content> and a defect in the <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content> have more widespread oral lesions and report more symptoms than <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OLL<\/jats:styled-content> patients without a concomitant defect in the <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010nine Caucasian patients (42 women and 7 men, mean age 61.0 \u00b1 10.3 years), with symptomatic <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> OLL<\/jats:styled-content> or stomatitis, and 29 matched healthy controls underwent a clinical oral and dermatological examination, oral mucosal biopsy and filaggrin genotyping (testing for R2447X, R501X, 2282del4). Smear tests for <jats:italic>Candida<\/jats:italic> spp. were performed in all patients to exclude oral candidiasis. Immunohistochemistry were performed using poly\u2010 and monoclonal filaggrin antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The immunoreactivity for filaggrin was significantly more intense in the oral mucosa in the patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OLL<\/jats:styled-content> compared with healthy controls (<jats:italic>P<\/jats:italic> = 0.000025). No difference was noted in the incidence of defects in the <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content> and active dermatoses between patients and healthy controls. No difference was noted in extension and number of symptoms reported by patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OLL<\/jats:styled-content> with or without a concomitant defect in the <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OLL<\/jats:styled-content> is associated with an altered distribution of filaggrin in the oral mucosa independently of defects in the <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>. Patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OLL<\/jats:styled-content> did not display more active dermatoses other than cutaneous <jats:styled-content style=\"fixed-case\">LP<\/jats:styled-content> when compared to healthy controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14098","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T07:22:55Z","timestamp":1482304975000},"page":"887-893","source":"Crossref","is-referenced-by-count":6,"title":["Filaggrin gene mutations and the distribution of filaggrin in oral mucosa of patients with oral lichen planus and healthy controls"],"prefix":"10.1111","volume":"31","author":[{"given":"K.R.","family":"Larsen","sequence":"first","affiliation":[{"name":"Department of Odontology Oral Pathology and Oral Medicine Faculty of Health and Medical Sciences University of Copenhagen Copenhagen N 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