{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:56:07Z","timestamp":1791280567412,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01IS13030"],"award-info":[{"award-number":["01IS13030"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Malignant Melanoma (\n                      <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                      ) is characterized by a growing incidence and a high malignant potential. Besides well\u2010defined prognostic factors such as tumour thickness and ulceration, the Mitotic Rate (\n                      <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n                      ) was included in the\n                      <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content>\n                      recommendations for diagnosis and treatment of\n                      <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                      . In daily routine, the identification of a single mitosis can be difficult on haematoxylin and eosin slides alone. Several studies showed a big inter\u2010 and intra\u2010individual variability in detecting the\n                      <jats:styled-content style=\"fixed-case\">MR<\/jats:styled-content>\n                      in\n                      <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                      even by very experienced investigators, thus raising the question for a computer\u2010assisted method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      The objective was to develop a software system for mitosis detection in\n                      <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                      on H&amp;E slides based on machine learning for diagnostic support.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We developed a computer\u2010aided staging support system based on image analysis and machine learning on the basis of 59\n                      <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                      specimens. Our approach automatically detects tumour regions, identifies mitotic nuclei and classifies them with respect to their diagnostic relevance. A convenient user interface enables the investigator to browse through the proposed mitoses for fast and efficient diagnosing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A quantitative evaluation on manually labelled ground truth data revealed that the tumour region detection yields a medium spatial overlap index (dice coefficient) of 0.72. For the mitosis detection, we obtained high accuracies of above 83%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      On the technical side, the developed\n                      <jats:styled-content style=\"fixed-case\">iD<\/jats:styled-content>\n                      ermatoPath software tool provides a novel approach for mitosis detection in\n                      <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>\n                      , which can be further improved using more training data such as dermatopathologist annotations. On the practical side, a first evaluation of the clinical utility was positive, albeit this approach provides most benefit for difficult cases in a research setting. Assuming all slides to be digitally processed and reported in the near future, this method could become a helpful additional tool for the pathologist.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.14126","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T17:08:29Z","timestamp":1484932109000},"page":"1137-1147","source":"Crossref","is-referenced-by-count":14,"title":["iDermatoPath \u2013 a novel software tool for mitosis detection in H&amp;E\u2010stained tissue sections of malignant melanoma"],"prefix":"10.1111","volume":"31","author":[{"given":"C.","family":"Andres","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"},{"name":"Labor f\u00fcr Dermatohistologie Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Andres\u2010Belloni","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hein","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Biedermann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sch\u00e4pe","sequence":"additional","affiliation":[{"name":"Definiens AG Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Brieu","sequence":"additional","affiliation":[{"name":"Definiens AG Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sch\u00f6nmeyer","sequence":"additional","affiliation":[{"name":"Definiens AG Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yigitsoy","sequence":"additional","affiliation":[{"name":"Definiens AG Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Ring","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Definiens AG Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Harder","sequence":"additional","affiliation":[{"name":"Definiens AG Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Zentrum f\u00fcr Krebsregisterdaten Robert Koch Institut (Malignes Melanom der Haut ICD\u201010 C43). URLhttp:\/\/www.krebsdaten.de\/Krebs\/DE\/Content\/Publikationen\/Krebs_in_Deutschland\/kid_2015\/kid_2015_c43_melanom.pdf(last accessed: 17 December 2015)."},{"key":"e_1_2_6_3_1","volume-title":"Cancer Facts and Figures 2014","author":"American Cancer Society","year":"2014"},{"key":"e_1_2_6_4_1","unstructured":"Melanoma.Bethesda Md: National Library of Medicine.2012. 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