{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:55:52Z","timestamp":1791280552198,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T00:00:00Z","timestamp":1489104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T00:00:00Z","timestamp":1489104000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001424","name":"American Liver Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001424","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Photodynamic therapy (\n PDT<\/jats:styled-content>\n ) is a well\u2010known technique that is often used for treating superficial precancerous and cancerous skin lesions. However, only a handful of studies, with a relatively small number of treated lesions, have been carried out on the effectiveness of\n PDT<\/jats:styled-content>\n for Bowen's disease (\n BD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n This study aimed to assess the effectiveness and recurrence risk of\n PDT<\/jats:styled-content>\n in the treatment of\n BD<\/jats:styled-content>\n . The secondary objectives were to determine what factors affected the response rates and the cosmetic result of the treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n In this retrospective observational study, the electronic patient charts at Sahlgrenska University Hospital (\n SUH<\/jats:styled-content>\n ) in Gothenburg, Sweden, were searched to find all patients diagnosed with\n BD<\/jats:styled-content>\n who were treated with\n PDT<\/jats:styled-content>\n between 1 January 2002 and 31 December 2014. Data were collected regarding clinical response at the first follow\u2010up visit, recurrences during later follow\u2010up visits and other relevant patient and tumour characteristics.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In total, 423\n BD<\/jats:styled-content>\n lesions in 335 patients were included in the study. The mean\n FU<\/jats:styled-content>\n duration was 11.2 months (range 0.2\u2013151 months). The complete response rate at the first\n FU<\/jats:styled-content>\n visit was 77.5% for all\n BD<\/jats:styled-content>\n lesions. During later\n FU<\/jats:styled-content>\n visits, another 60 recurrences were observed, which resulted in a recurrence rate of 18.3%. Thus, the overall clearance rate after\n FU<\/jats:styled-content>\n was 63.4% for all\n BD<\/jats:styled-content>\n lesions. Significant risk factors for unsuccessful treatment in this study were large lesion size (>2 cm) and a single\n PDT<\/jats:styled-content>\n session.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This study shows that\n PDT<\/jats:styled-content>\n is a relatively effective treatment modality for\n BD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.14164","type":"journal-article","created":{"date-parts":[[2017,2,11]],"date-time":"2017-02-11T21:52:42Z","timestamp":1486849962000},"page":"1289-1294","source":"Crossref","is-referenced-by-count":37,"title":["Effectiveness of photodynamic therapy in Bowen's disease: a retrospective observational study in 423 lesions"],"prefix":"10.1111","volume":"31","author":[{"given":"O.","family":"Zaar","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital Institute of Clinical Sciences at the Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Fougelberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital Institute of Clinical Sciences at the Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Hermansson","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital Institute of Clinical Sciences at the Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gillstedt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital Institute of Clinical Sciences at the Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.\u2010M.","family":"Wennberg\u2010Lark\u00f6","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital Institute of Clinical Sciences at the Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Paoli","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sahlgrenska University Hospital Institute of Clinical Sciences at the Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,10]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"The Swedish Cancer Registry of the National Board of Health and Welfare.[Cancer incidence in Sweden 2014].2015[cited 2016 May 17]. 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