{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:33:20Z","timestamp":1789788800328,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Common loss\u2010of\u2010function mutations in filaggrin gene (FLG<\/jats:styled-content><\/jats:italic>) represent a strong genetic risk factor for atopic dermatitis (AD<\/jats:styled-content>). Homozygous mutation carriers typically display ichthyosis vulgaris (IV<\/jats:styled-content>) and many have concomitant AD<\/jats:styled-content>. Previously, homozygous, but not heterozygous, filaggrin gene mutations have been associated with squamous cell carcinomas.<\/jats:p><\/jats:sec>Objective<\/jats:title>The first objective was to examine the association between FLG<\/jats:styled-content><\/jats:italic> mutations and actinic keratosis (AK<\/jats:styled-content>). The second objective was to investigate the occurrence of AK<\/jats:styled-content> in patients with IV<\/jats:styled-content> and AD<\/jats:styled-content>, respectively.<\/jats:p><\/jats:sec>Methods<\/jats:title>FLG<\/jats:styled-content><\/jats:italic> mutation status in patients with AK<\/jats:styled-content> was compared with controls from the general population. Furthermore, based on nationwide data from Danish registers, we compared the risk of AK<\/jats:styled-content> in patients with IV<\/jats:styled-content>, AD<\/jats:styled-content> and psoriasis, respectively.<\/jats:p><\/jats:sec>Results<\/jats:title>The prevalence of homozygous FLG<\/jats:styled-content><\/jats:italic> mutations was significantly higher in the AK<\/jats:styled-content> group (n<\/jats:italic> = 4, 0.8%) in comparison with the control group (n<\/jats:italic> = 18, 0.2%), whereas the prevalence of heterozygous FLG<\/jats:styled-content><\/jats:italic> mutations was lower. In hospital registry data, patients with AD<\/jats:styled-content> exhibited an increased risk of AK<\/jats:styled-content> than did psoriasis controls (adjusted OR<\/jats:styled-content> 1.46; [95% CI<\/jats:styled-content> 1.12\u20131.90]), whereas no difference in risk was observed between patients with IV<\/jats:styled-content> and AD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This study indicates an increased susceptibility to AK<\/jats:styled-content> in individuals with homozygous, but not heterozygous, FLG<\/jats:styled-content><\/jats:italic> mutations and in patients with AD<\/jats:styled-content> compared to psoriasis. Whether a reduction or absence of epidermal filaggrin could contribute to the susceptibility to AK<\/jats:styled-content> in patients with IV<\/jats:styled-content> and AD<\/jats:styled-content> is unknown and additional research is needed to further explore this relationship.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14172","type":"journal-article","created":{"date-parts":[[2017,2,18]],"date-time":"2017-02-18T07:52:55Z","timestamp":1487404375000},"page":"1038-1043","source":"Crossref","is-referenced-by-count":17,"title":["Filaggrin loss\u2010of\u2010function mutations, atopic dermatitis and risk of actinic keratosis: results from two cross\u2010sectional studies"],"prefix":"10.1111","volume":"31","author":[{"given":"Y.M.F.","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"},{"name":"Department of Cardiology Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Egeberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"},{"name":"Department of Cardiology Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Balslev","sequence":"additional","affiliation":[{"name":"Department of Pathology Herlev and Gentofte Hospital University of Copenhagen Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.L.T.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[{"name":"Department of Pathology Herlev and Gentofte Hospital University of Copenhagen Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.B.","family":"Szecsi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Stender","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kaae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Linneberg","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health the Capital Region of Denmark Copenhagen Denmark"},{"name":"Department of Clinical Experimental Research Rigshospitalet Copenhagen Denmark"},{"name":"Department of Clinical Medicine Faculty of Health and Medical Sciences University of Copenhagen 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