{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:59:52Z","timestamp":1791388792403,"version":"4.3.3"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acquired perforating dermatosis (<jats:styled-content style=\"fixed-case\">APD<\/jats:styled-content>) is a rare group of skin disorders of unknown aetiology and pathogenesis and is associated with several systemic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We review the clinicopathological features, associated systemic diseases and treatment response in a series of <jats:styled-content style=\"fixed-case\">APD<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective observational study of all patients histologically diagnosed with <jats:styled-content style=\"fixed-case\">APD<\/jats:styled-content> in Hospital San Jorge (Huesca, Spain) between 2002 and 2014. Demographic and clinical features were collected from medical records. Statistical analyses were carried out using <jats:styled-content style=\"fixed-case\">SPSS<\/jats:styled-content> software (version 20.0; <jats:styled-content style=\"fixed-case\">IBM<\/jats:styled-content> Corp, Armonk, <jats:styled-content style=\"fixed-case\">NY<\/jats:styled-content>, USA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population consisted of 31 patients (19 women and 12 men), with a mean age of 54 years. Reactive perforating collagenosis (<jats:italic>n<\/jats:italic> = 15, 45%) was the most common histopathologic type. The most frequently affected area was the lower limbs (66.6%, <jats:italic>n<\/jats:italic> = 22), and pruritus was present in 19 patients (61.3%, <jats:italic>P<\/jats:italic> = 0.005). Arterial hypertension (30.3%) was the most common associated condition. Five patients were receiving treatment with infliximab when diagnosed with <jats:styled-content style=\"fixed-case\">APD<\/jats:styled-content>. Most patients responded to topical steroids and oral antihistamines (<jats:italic>n<\/jats:italic> = 15).<\/jats:p><\/jats:sec><jats:sec><jats:title>Limitations<\/jats:title><jats:p>This study is retrospective, and the sample size is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acquired perforating dermatosis is an underdiagnosed dermatosis frequently associated with systemic disorders. Its pathogenesis may involve vascular damage, not only in patients with diabetes, but also in those with arterial hypertension and chronic venous insufficiency. Control of pruritus and underlying extracutaneous disorders, as well as discontinuation of the treatment with biologics, are important aspects of the management of this dermatosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14220","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T09:33:08Z","timestamp":1489656788000},"page":"1757-1763","source":"Crossref","is-referenced-by-count":61,"title":["Acquired perforating dermatosis: clinicopathological study of 31 cases, emphasizing pathogenesis and treatment"],"prefix":"10.1111","volume":"31","author":[{"given":"A.J.","family":"Garc\u00eda\u2010Malinis","sequence":"first","affiliation":[{"name":"Unit of Dermatology Hospital San Jorge Huesca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"del Valle S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital San Jorge Huesca 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