{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:59:54Z","timestamp":1792828794345,"version":"4.5.0"},"reference-count":89,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002066","name":"GlaxoSmithKline foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Biomarkers useful for the evaluation and management of patients with chronic spontaneous urticaria (<jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content>) are not currently available. A review of various clinical and laboratory markers that have been studied to assess their value for determining the severity or predicting the evolution of disease in adult patients with <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content> was carried out. A search of the medical literature on PubMed and <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> including the terms urticaria, chronic urticaria, chronic idiopathic urticaria, <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content>, severity, prognosis and treatment was performed. Based on our review of the literature, among the clinical markers studied, higher age at onset, being female, long disease duration and aspirin\/<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> hypersensitivity may be linked to both severe <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content> and a long time to spontaneous remission. In addition, a positive autologous serum skin test (<jats:styled-content style=\"fixed-case\">ASST<\/jats:styled-content>) may be associated with severe <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content>, and comorbidity of inducible urticaria and concomitant recurrent angio\u2010oedema may be linked to longer <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content> duration. Potential biomarkers of <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content> severity and\/or duration include basophil numbers and susceptibility to activation, inflammatory markers, markers of activation of the extrinsic coagulation pathway, immunoglobulin E and vitamin D. Although the described markers are promising, further studies on representative and well\u2010characterized patient populations are needed to determine the value of these clinical and biological markers for predicting the severity and course of disease in patients with <jats:styled-content style=\"fixed-case\">CSU<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jdv.14221","type":"journal-article","created":{"date-parts":[[2017,3,16]],"date-time":"2017-03-16T07:52:44Z","timestamp":1489650764000},"page":"964-971","source":"Crossref","is-referenced-by-count":77,"title":["Factors linked to disease severity and time to remission in patients with chronic spontaneous urticaria"],"prefix":"10.1111","volume":"31","author":[{"given":"M.","family":"S\u00e1nchez\u2010Borges","sequence":"first","affiliation":[{"name":"Allergy and Clinical Immunology Department Centro M\u00e9dico Docente La Trinidad Caracas Venezuela"},{"name":"Allergy Service Cl\u00ednica El Avila Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Caballero\u2010Fonseca","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Department Centro M\u00e9dico Docente La Trinidad Caracas Venezuela"},{"name":"Allergy Service Centro M\u00e9dico de Caracas Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Capriles\u2010Hulett","sequence":"additional","affiliation":[{"name":"Allergy and Clinical Immunology Department Centro M\u00e9dico Docente La Trinidad Caracas Venezuela"},{"name":"Allergy Service Centro M\u00e9dico de Caracas Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gonz\u00e1lez\u2010Aveledo","sequence":"additional","affiliation":[{"name":"Dermatology Service Centro M\u00e9dico de Caracas Caracas Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Allergie\u2010Centrum Charit\u00e9\/ECARF Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03840.x"},{"key":"e_1_2_5_3_1","first-page":"214","article-title":"Epidemiology of urticaria in Spain","volume":"14","author":"Gaig P","year":"2004","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02496.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_5_6_1","first-page":"210","article-title":"Subtypes of chronic urticaria in patients attending allergy clinics in Venezuela","volume":"46","author":"S\u00e1nchez\u2010Borges M","year":"2014","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01920.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02840.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12078"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2008.08035"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01880.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03070140041004"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.03.003"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01185.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08694.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13644"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02483-1"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.05.069"},{"key":"e_1_2_5_19_1","first-page":"161","article-title":"Chronic urticaria in childhood: natural course and etiology","volume":"51","author":"Harris A","year":"1983","journal-title":"Ann Allergy"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322349"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00473.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345696"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2016.04.011"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346896"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1981.tb15306.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1969.tb16041.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04582.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.116217"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-010-1933-8"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60360-2"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.04.001"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1443"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02557.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12658"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2015.30.6.705"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12313"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2012.4.6.326"},{"key":"e_1_2_5_38_1","first-page":"279","article-title":"Epidemiologic features in patients with antihistamine\u2010resistant chronic urticaria","volume":"62","author":"S\u00e1nchez\u2010Borges M","year":"2015","journal-title":"Rev Alerg Mex"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.156458"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000090656"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.04.037"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.047"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2015.11.025"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03664.x"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-2-19"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2011.08.013"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.11.016"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12413"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452626"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.00027.x"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01589.x"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2004.10.007"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1994.tb02284.x"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.146.2.671"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.09.005"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1974.tb01384.x"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108405"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02212.x"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70283-0"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60449-8"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2014.29.1.43"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.55"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02222.x"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03473.x"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.143607"},{"key":"e_1_2_5_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03789.x"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2007.02450.x"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-10-22"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02069.x"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.03.016"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02168.x"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.08.043"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01514.x"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1159\/000155748"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02506.x"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2014.04.002"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314370"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2012.4.6.311"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014794"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2015.27.4.423"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40413-015-0066-z"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0307-6938.2001.00962.x"},{"key":"e_1_2_5_83_1","first-page":"201","article-title":"Autologous serum skin test in chronic idiopathic urticaria: prevalence, correlation and clinical implications","volume":"24","author":"Kulthanan K","year":"2006","journal-title":"Asian Pac J Allergy Immunol"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.39690"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70495-0"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550410026939"},{"key":"e_1_2_5_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2010.04.014"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e31820233fc"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.77454"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2016.8.2.115"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T13:01:54Z","timestamp":1695042114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,4]]},"references-count":89,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/jdv.14221"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14221","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,4]]}}}