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Bilastine is a highly effective H<jats:sub>1<\/jats:sub>\u2010antihistamine even when used at the basic dose of 20 mg daily. Its facilitated uptake after oral dosage gives it a rapid onset and long duration of action. In both wheal and flare studies and in urticaria updosing fourfold showed increased effectiveness. With respect to somnolence, bilastine is a substrate for P\u2010glycoprotein, a membrane pump which prevents it crossing the blood\u2013brain barrier. Consequently, bilastine is a practically \u2018non\u2010sedating\u2019 H<jats:sub>1<\/jats:sub>\u2010antihistamine. In conclusion, the excellent profile of bilastine in both efficacy and safety make it the ideal H<jats:sub>1<\/jats:sub>\u2010antihistamine for updosing the daily dose fourfold in difficult\u2010to\u2010treat urticaria as recommended by the EAACI\/GA<jats:sup>2<\/jats:sup>LEN\/EDF\/WAO guideline for the management of urticaria.<\/jats:p>","DOI":"10.1111\/jdv.14305","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T16:22:38Z","timestamp":1493828558000},"page":"1447-1452","source":"Crossref","is-referenced-by-count":22,"title":["Bilastine: a new H<sub>1<\/sub>\u2010antihistamine with an optimal profile for updosing in urticaria"],"prefix":"10.1111","volume":"31","author":[{"given":"M.K.","family":"Church","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Allergy Centre Charit\u00e9 Charit\u00e9 Universit\u00e4tsmedizin Berlin 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