{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:22:28Z","timestamp":1791397348091,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T00:00:00Z","timestamp":1496707200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Anogenital warts (\n AGW<\/jats:styled-content>\n ) are one of the most prevalent sexually transmitted disease worldwide. Approximately, 90% of\n AGW<\/jats:styled-content>\n s are related to infection by\n HPV<\/jats:styled-content>\n 6 and 11. However,\n AGW<\/jats:styled-content>\n have been associated with infection by multiple genotypes, including\n HR<\/jats:styled-content>\n \u2010\n HPV<\/jats:styled-content>\n , which may be associated with a long\u2010term increased risk of anogenital cancer.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n This observational prospective epidemiological study aims to estimate the type\u2010specific\n HPV<\/jats:styled-content>\n distribution on incident\n AGW<\/jats:styled-content>\n s in both genders, and additionally to assess the frequency of anal and oral\n HPV<\/jats:styled-content>\n infection in patients with\n AGW<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n According to defined inclusion criteria, individuals with incident clinical diagnosis of\n AGW<\/jats:styled-content>\n s were recruited in seven Portuguese Centres.\n HPV<\/jats:styled-content>\n genotyping was performed using\n CLART HPV<\/jats:styled-content>\n 2 test.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Between November 2012 and March 2014, 162 women and 400 men (mean age: 34 years), were enrolled. After exclusion of patients with unqualified\n AGW<\/jats:styled-content>\n samples,\n HPV<\/jats:styled-content>\n was detected in 95.3% (505\/530)\n AGW<\/jats:styled-content>\n patients, 96.8% males and 91.6% females. Among men who have sex with men,\n HPV<\/jats:styled-content>\n was detected in 98.5% patients.\n HPV<\/jats:styled-content>\n 6 and\/or\n HPV<\/jats:styled-content>\n 11 were the most frequent genotypes (87.5%), and\n HPV<\/jats:styled-content>\n 16 the most common\n HR<\/jats:styled-content>\n \u2010\n HPV<\/jats:styled-content>\n (9.2%). Infection with\n HPV<\/jats:styled-content>\n 6\/11 and any\n HR<\/jats:styled-content>\n \u2010\n HPV<\/jats:styled-content>\n was observed in 35.8% patients.\n HPV<\/jats:styled-content>\n prevalence on the anal canal and oral mucosa was 83.1% and 15.0%, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Incident\n AGW<\/jats:styled-content>\n s were more frequent in males than in females.\n LR<\/jats:styled-content>\n \u2010\n HPV<\/jats:styled-content>\n s were more common among males and\n HR<\/jats:styled-content>\n \u2010\n HPV<\/jats:styled-content>\n s among females.\n HPV<\/jats:styled-content>\n 6 and 11 were the most common genotypes on both genders. However, there was also a high prevalence of\n HR<\/jats:styled-content>\n \u2010\n HPV<\/jats:styled-content>\n s, particularly of\n HPV<\/jats:styled-content>\n 16.\n AGW<\/jats:styled-content>\n s represent a clinical marker of both anal and oral\n HPV<\/jats:styled-content>\n infections, including anal\n HR<\/jats:styled-content>\n \u2010\n HPV<\/jats:styled-content>\n infections in women and men who have sex with men. The\n HERCOLES<\/jats:styled-content>\n study could be a clue to further investigations concerning\n HPV<\/jats:styled-content>\n burden of disease by gender and sexual behaviour.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.14311","type":"journal-article","created":{"date-parts":[[2017,5,9]],"date-time":"2017-05-09T10:05:09Z","timestamp":1494324309000},"page":"1342-1348","source":"Crossref","is-referenced-by-count":20,"title":["Epidemiology of human papillomavirus on anogenital warts in Portugal \u2013 The\n HERCOLES<\/scp>\n study"],"prefix":"10.1111","volume":"31","author":[{"given":"J.","family":"Azevedo","sequence":"first","affiliation":[{"name":"Centro de Sa\u00fade da Lapa Consulta DST Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pista","sequence":"additional","affiliation":[{"name":"Investigador Independente Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lisboa","sequence":"additional","affiliation":[{"name":"Hospital de S. Jo\u00e3o \u2013 Faculdade de Medicina Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Santo","sequence":"additional","affiliation":[{"name":"Centro de Sa\u00fade da Lapa Consulta DST Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Universidade do Porto (CIDES & CINTESIS) Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Cunha","sequence":"additional","affiliation":[{"name":"Sanofi Pasteur MSD Portugal Amadora Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the HERCOLES Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00177-0"},{"issue":"1","key":"e_1_2_6_3_1","first-page":"S1","article-title":"The epidemiology of genital human papillomavirus infection","volume":"24","author":"Trottier H","year":"2006","journal-title":"Vaccine"},{"key":"e_1_2_6_4_1","unstructured":"International Agency for Research on Cancer.IARC Monographs on the evaluation on carcinogenic risk to humans: Vol 100 B a review of human carcinogens. 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