{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:31:12Z","timestamp":1793046672624,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T00:00:00Z","timestamp":1497916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"European Union's ICT Policy Support Programme"},{"name":"Competitiveness and Innovation Framework Programme","award":["621015"],"award-info":[{"award-number":["621015"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>A clear distinction between actinic keratosis (AK<\/jats:styled-content>), Bowen's disease (BD<\/jats:styled-content>) and squamous cell carcinoma (SCC<\/jats:styled-content>) cannot reliably be made by clinical and dermoscopic evaluation alone. Dynamic optical coherence tomography (D\u2010OCT<\/jats:styled-content>) is a novel angiographic variant of OCT<\/jats:styled-content> that allows for non\u2010invasive, in vivo<\/jats:italic> evaluation of the cutaneous microvascular morphology.<\/jats:p><\/jats:sec>Objective<\/jats:title>To investigate the microvascular structures of AK<\/jats:styled-content>, BD<\/jats:styled-content> and invasive SCC<\/jats:styled-content> using D\u2010OCT<\/jats:styled-content> in order to gain insights into the microvascular morphology of lesions in the spectrum of keratinocyte skin cancers.<\/jats:p><\/jats:sec>Methods<\/jats:title>Forty\u2010seven patients with a total of 54 lesions (18 AK<\/jats:styled-content>, 12 BD<\/jats:styled-content> and 24 SCC<\/jats:styled-content>) were included in the study. D\u2010OCT<\/jats:styled-content> still images of AK<\/jats:styled-content>, BD<\/jats:styled-content> and SCC<\/jats:styled-content> at three predefined skin depths were prepared and randomized, creating a study set of 162 D\u2010OCT<\/jats:styled-content> images. Three observers performed blinded evaluations of the randomized study set assessing multiple parameters including the different types of vascular morphology. Non\u2010blinded quantitative measurements of vascular diameter were also performed.<\/jats:p><\/jats:sec>Results<\/jats:title>The blinded observer analysis suggests that D\u2010OCT<\/jats:styled-content> evaluation of the vascular morphology may aid in distinguishing AK<\/jats:styled-content>, BD<\/jats:styled-content> and SCC<\/jats:styled-content> lesions. We identified two vascular shapes that presented significantly differently across the lesion types, namely \u2018blobs\u2019 and \u2018curves\u2019. A strong presence of blobs at 300 \u03bcm skin depth was characteristically seen in a third of BD<\/jats:styled-content> cases, while not or only slightly present in AK<\/jats:styled-content> and SCC<\/jats:styled-content> lesions. Vascular curves were predominantly present in AK<\/jats:styled-content> lesions.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We identified various vascular D\u2010OCT<\/jats:styled-content> features that may aid in non\u2010invasively differentiating subtypes within the keratinocyte skin cancer spectrum.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14335","type":"journal-article","created":{"date-parts":[[2017,5,14]],"date-time":"2017-05-14T10:16:23Z","timestamp":1494756983000},"page":"1655-1662","source":"Crossref","is-referenced-by-count":48,"title":["In vivo<\/i> microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using dynamic optical coherence tomography"],"prefix":"10.1111","volume":"31","author":[{"given":"L.","family":"Themstrup","sequence":"first","affiliation":[{"name":"Department of Dermatology Zealand University Hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Welzel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology General Hospital Augsburg Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Michelson Diagnostics Ltd. 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