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A hyperactivity of the hypothalamic\u2010pituitary\u2010adrenal axis (the HPA axis) in patients affected by <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients) was proposed to be a neuroendocrine response to stress. Still little is known about melanocyte\u2010stimulating hormone (MSH) and cortisol production in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the study was to compare trends in a production of <jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content> and cortisol in patients with <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p><jats:italic>Plasma<\/jats:italic> concentrations of free cortisol and <jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content> were measured in 43 <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients (35.5 \u00b1 10.6 years) and 37 healthy subjects (35.9 \u00b1 10.5 years) selected from the Dermatology Outpatient Clinic at Medical University of Silesia in Katowice, Poland. Results were submitted to statistical analysis with Shapiro\u2013Wilk <jats:italic>W<\/jats:italic>\u2010test and subsequently nonparametric (Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test) or parametric (Student's <jats:italic>t<\/jats:italic>\u2010test) statistics were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean plasma level of <jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content> was 5.39 ng\/mL in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients and 5.71 ng\/mL in healthy controls. The difference between groups was non\u2010significant (<jats:italic>P<\/jats:italic> = 0.435), but the control group manifested higher values of <jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content> (Q75 = 13.6 ng\/mL vs Q75 = 5.98 ng\/mL) and this tendency was especially stronger in females. <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients had greater mean plasma level of cortisol (157.63 \u00b1 91.16 \u00b5g\/L) than healthy controls (123.32 \u00b1 71.28 \u00b5g\/L); however, the difference between them was also non\u2010significant (<jats:italic>P<\/jats:italic> = 0.063). No sex\u2010dependent tendency to a greater production of cortisol was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Expectations of disturbances in production of <jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content> and cortisol were not fulfilled. Neither <jats:styled-content style=\"fixed-case\">MSH<\/jats:styled-content> nor cortisol plasma levels appear to be clearly changed in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14346","type":"journal-article","created":{"date-parts":[[2017,5,18]],"date-time":"2017-05-18T07:06:41Z","timestamp":1495091201000},"page":"1555-1561","source":"Crossref","is-referenced-by-count":8,"title":["Alopecia areata \u2013 hyperactivity of the hypothalamic\u2013pituitary\u2013adrenal axis is a myth?"],"prefix":"10.1111","volume":"31","author":[{"given":"B.","family":"Bergler\u2010Czop","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine in Katowice Medical University of Silesia in Katowice Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Mizio\u0142ek","sequence":"additional","affiliation":[{"name":"Department of Dermatology Andrzej 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