{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:16:55Z","timestamp":1791505015708,"version":"4.3.4"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,6,9]],"date-time":"2017-06-09T00:00:00Z","timestamp":1496966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rosacea is a common skin disease characterized by facial erythema, telangiectasia, papules and pustules. Helicobacter pylori infection has been suggested to play a role in the etiopathogenesis of rosacea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically review and meta\u2010analyse the relationship between rosacea and infection with Helicobacter pylori.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A literature search was performed using PubMed,\n                      <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>\n                      and Web of Science. Data extraction and analyses were performed on descriptive data. Study quality was assessed using the Newcastle\u2013Ottawa Scale. Random\u2010effects models with DerSimonian\u2013Laird methods were utilized to estimate pooled odds ratios (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      s), with 95% confidence intervals (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      s). Heterogeneity of results was assessed using\n                      <jats:italic>I\u00b2<\/jats:italic>\n                      statistics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 454 articles were identified and 42 full\u2010text articles were chosen for further review. Fourteen studies were included in the quantitative meta\u2010analysis, comprising a total of 928 rosacea patients and 1527 controls. The overall association between Helicobacter pylori infection and rosacea was non\u2010significant (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      1.68, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.00\u20132.84,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.052), but analysis restricted to\n                      <jats:italic>C\u2010urea breath test<\/jats:italic>\n                      showed a significant association (\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      3.12, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1.92\u20135.07,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001). Effect of eradication treatment on rosacea symptoms was assessed in seven studies, but without significant effect (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      1.28, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      0.98\u20131.67,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.069).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This meta\u2010analysis found weak associations between rosacea and Helicobacter pylori infection as well as an effect of Helicobacter pylori therapy on rosacea symptoms, albeit that these did not reach statistical significance. Whether a pathogenic link between the two conditions exists, or whether Helicobacter pylori infection represents a proxy for other factors remains unknown.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.14352","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T20:49:10Z","timestamp":1495572550000},"page":"2010-2015","source":"Crossref","is-referenced-by-count":71,"title":["Rosacea is associated with Helicobacter pylori: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"31","author":[{"given":"A\u2010H.R.","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Egeberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen 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