{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T13:57:37Z","timestamp":1769263057325,"version":"3.49.0"},"reference-count":49,"publisher":"Wiley","issue":"S5","license":[{"start":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T00:00:00Z","timestamp":1502668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Actinic keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>) is a characteristic skin lesion on skin areas of subjects with mainly phototype I and phototype <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, or with specific genetic factors and who are exposed to prolonged ultraviolet radiation. <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> may be considered a precursor of <jats:italic>in\u00a0situ<\/jats:italic> squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>), a type of non\u2010melanoma skin cancer (<jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content>). However, it is still not possible to predict which <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> lesions will develop into <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>. Early treatment of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> is therefore recommended. Despite the increasing number of patients with <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> developing into <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>, to date, there is still no clear suggestion of therapeutic strategy for <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>. Current treatment consists of a multitude of topical lesion\u2010directed or field\u2010directed therapies or a combination of both. Recently, orally administered nicotinamide has shown to significantly reduce rates of new <jats:styled-content style=\"fixed-case\">NMSC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> in high\u2010risk patients. This study aims to provide an update on the most relevant information about <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> and to provide an insight into current and new treatment options.<\/jats:p>","DOI":"10.1111\/jdv.14375","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T12:40:15Z","timestamp":1502714415000},"page":"13-17","source":"Crossref","is-referenced-by-count":24,"title":["New and current preventive treatment options in actinic keratosis"],"prefix":"10.1111","volume":"31","author":[{"given":"P.","family":"Arenberger","sequence":"first","affiliation":[{"name":"Department of Dermatovenereology Charles University Third Faculty of Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Arenbergerova","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology Charles University Third Faculty of Medicine Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06318.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91658-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00467.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970301)79:5<920::AID-CNCR8>3.0.CO;2-F"},{"key":"e_1_2_6_6_1","first-page":"201","article-title":"Progression of actinic keratosis to squamous cell carcinoma revisited: clinical and treatment implications","volume":"87","author":"Feldman SR","year":"2011","journal-title":"Cutis"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.9.1216"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107497"},{"key":"e_1_2_6_9_1","first-page":"651","article-title":"Development of a treatment algorithm for actinic keratoses: a European Consensus","volume":"18","author":"Stockfleth E","year":"2008","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12840"},{"key":"e_1_2_6_11_1","first-page":"467","article-title":"Actinic keratosis","volume":"94","author":"Dejaco D","year":"2015","journal-title":"Laryngorhinootologie"},{"key":"e_1_2_6_12_1","first-page":"379","article-title":"Actinic keratosis and squamous cell carcinoma: clinical and pathological features","volume":"150","author":"Filosa A","year":"2015","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23396"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.134"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33224.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.06.009"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.4.447"},{"key":"e_1_2_6_18_1","first-page":"471","article-title":"New concepts on the origin of squamous cell carcinomas of the skin: solar (senile) keratosis with squamous cell carcinoma\u2013a clinicopathologic and histochemical study","volume":"6","author":"Bendl BJ","year":"1970","journal-title":"Proc Natl Cancer Conf"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1995.tb00141.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07860.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07121.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.113935"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-5-30"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04474.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.09.053"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soncn.2013.06.002"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61196-X"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17040372"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-012-9619-0"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.06.024"},{"key":"e_1_2_6_31_1","first-page":"3669","article-title":"Reduced serum 25\u2010hydroxyvitamin D levels in stage IV melanoma patients","volume":"29","author":"Nurnberg B","year":"2009","journal-title":"Anticancer Res"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710615105"},{"key":"e_1_2_6_33_1","first-page":"335","article-title":"Actinic keratosis: how to differentiate the good from the bad ones?","volume":"16","author":"Quaedvlieg PJ","year":"2006","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2015.1221"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.281"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0738-081X(02)00221-3"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/546813"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.02.011"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.09.051"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07692.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-015-0070-9"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05776.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2017.1303568"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15304"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13138"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13228"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506197"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S31930"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962012000300012"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.535"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T14:42:11Z","timestamp":1694529731000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,14]]},"references-count":49,"journal-issue":{"issue":"S5","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/jdv.14375"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14375","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,14]]}}}