{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:27:02Z","timestamp":1759814822649},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,7]],"date-time":"2017-07-07T00:00:00Z","timestamp":1499385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Laboratoires Vichy, France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acne in adult women is an increasing reason for dermatological consultations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to assess in adult women with mild acne the efficacy and tolerance of a daily adjunctive application of a skincare (Normaderm<jats:sup>\u00ae<\/jats:sup>, Laboratoires Vichy, France) to a fixed combination of adapalene\/benzoyl peroxide daily or every other evening and a standard emollient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects were randomized to receive the fixed combination applied either every evening or every other evening and a daily application of the standard emollient and the test care or a once daily application of the fixed combination and the standard emollient alone. Clinical evaluations at Day 0, Day 45 and Day 90 included the count of acne lesions, assessment of clinical improvement and local tolerance. The quantitative lipid profile of the stratum corneum of the forehead was also determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 90 days of application, acne had improved in all 299 subjects with a statistically significant difference in favour of the test care regimens (<jats:italic>P<\/jats:italic> &lt; 0.05). Moreover, skin quality, subject satisfaction, skin discomfort and sebum composition were in favour of these regimens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, the tested skincare combined with a fixed adapalene and benzoyl peroxide combination provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14379","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T08:02:39Z","timestamp":1496390559000},"page":"1727-1731","source":"Crossref","is-referenced-by-count":8,"title":["A skincare combined with combination of adapalene and benzoyl peroxide provides a significant adjunctive efficacy and local tolerance benefit in adult women with mild acne"],"prefix":"10.1111","volume":"31","author":[{"given":"A.","family":"Bouloc","sequence":"first","affiliation":[{"name":"Vichy Laboratoires Asni\u00e8res sur Seine France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Roo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Sur Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Imko\u2010Walczuk","sequence":"additional","affiliation":[{"name":"Dermatology Clinic Copernicus\u2010 Podmiot Leczniczy Gdansk Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Moga","sequence":"additional","affiliation":[{"name":"Synelvia SAS Lab\u00e8ge France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Chadoutaud","sequence":"additional","affiliation":[{"name":"Clinreal Online Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Dr\u00e9no","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Cancerology H\u00f4tel Dieu Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)80056-5"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12061"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12757"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.12.037"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13776"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13675"},{"key":"e_1_2_5_8_1","first-page":"65","article-title":"Comedolysis by a lipohydroxyacid formulation in acne\u2010prone subjects","volume":"13","author":"Uhoda E","year":"2003","journal-title":"Eur J Dermatol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2007.00296.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2009.00418.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21101306"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2016.1146253"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13579"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.2.8472"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12208"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T14:45:24Z","timestamp":1694961924000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,7]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/jdv.14379"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14379","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,7]]}}}