{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:45:23Z","timestamp":1791938723922,"version":"4.3.4"},"reference-count":171,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,24]],"date-time":"2017-09-24T00:00:00Z","timestamp":1506211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acne vulgaris is a ubiquitary skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from bacterial colonization of hair follicles by Propionibacterium acnes, androgen\u2010induced increased sebum production, altered keratinization and inflammation. Here, we review our current understanding of the genetic architecture of this intriguing disease. We analysed genomewide association studies (<jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>) and candidate genes studies for acne vulgaris. Moreover, we included<jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>studies for the associated disease polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>). Overall, the available data revealed sixteen genetic loci flagged by single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s), none of which has been confirmed yet by independent studies. Moreover, a<jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>for<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>identified 21 susceptible loci. The genetic architecture is complex which has been revealed by<jats:styled-content style=\"fixed-case\">GWAS<\/jats:styled-content>. Further and larger studies in different populations are required to confirm or disprove results from candidate gene studies as well to identify signals that may overlap between different populations. Finally, studies on rare genetic variants in acne and associated diseases like<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>may deepen our understanding of its pathogenesis.<\/jats:p>","DOI":"10.1111\/jdv.14385","type":"journal-article","created":{"date-parts":[[2017,6,8]],"date-time":"2017-06-08T01:56:42Z","timestamp":1496887002000},"page":"1978-1990","source":"Crossref","is-referenced-by-count":49,"title":["Genetic architecture of acne vulgaris"],"prefix":"10.1111","volume":"31","author":[{"given":"R.","family":"Lichtenberger","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Division of Genetics and Molecular Medicine King's College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Genetics and Molecular Medicine King's College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Barker","sequence":"additional","affiliation":[{"name":"Division of Genetics and Molecular Medicine King's College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Navarini","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Zurich Zurich Switzerland"},{"name":"Division of Genetics and Molecular Medicine King's College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363150-00005"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.0285a.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6171.1109"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-139X(97)00277-2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.47"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.012"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06274.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113451"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06387.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067819"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000068476"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.045"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.d01-1144.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1164"},{"key":"e_1_2_5_17_1","first-page":"U1018","article-title":"Acne prevalence in secondary school students and their perceived difficulty in accessing acne treatment","volume":"117","author":"Purvis D","year":"2004","journal-title":"N Z Med J"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0001566000005948"},{"key":"e_1_2_5_19_1","first-page":"190","article-title":"Genetic and environmental influences on acne in adolescent twins","volume":"4","author":"Kirk KMED","year":"2001","journal-title":"Twin Res Human Genet"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19621.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.02022.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03590.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb02433.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546639809160698"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1997.00099.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.03.008"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3870"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5020"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.9.3259.bloodjournal8893259"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-07-343566"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0812254106"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.07.023"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12754"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/19539"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/19531"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2932"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00780.x"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E10-11-0879"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.10.3758"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-13-2"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2009.04.008"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.3.1535"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.438"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200508196"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.10.4241-4254.2004"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1017"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.6.627"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.19.5361"},{"key":"e_1_2_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62047-0"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1374-4"},{"key":"e_1_2_5_51_1","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1210\/mend.13.11.0369","article-title":"Multiple androgen response elements and a Myc consensus site in the androgen receptor (AR) coding region are involved in androgen\u2010mediated up\u2010regulation of AR messenger RNA","volume":"13","author":"Grad JM","year":"1999","journal-title":"Mol Endocrinol"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.278705"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20462"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1081\/ERC-100107177"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.09.014"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1708"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1864"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04946.x"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067818"},{"key":"e_1_2_5_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-008-0871-0"},{"key":"e_1_2_5_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02858.x"},{"key":"e_1_2_5_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1050-7"},{"key":"e_1_2_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2012.07.001"},{"key":"e_1_2_5_64_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356388"},{"key":"e_1_2_5_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087806"},{"key":"e_1_2_5_66_1","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1210\/jcem.87.8.8715","article-title":"Comment: the methionine 196 arginine polymorphism in exon 6 of the TNF receptor 2 gene (TNFRSF1B) is associated with the polycystic ovary syndrome and hyperandrogenism","volume":"87","author":"Peral B","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_5_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-006-0159-7"},{"key":"e_1_2_5_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.058917"},{"key":"e_1_2_5_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-010-0366-z"},{"key":"e_1_2_5_70_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.8.3158-3165.1995"},{"key":"e_1_2_5_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.04.010"},{"key":"e_1_2_5_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02066.x"},{"key":"e_1_2_5_73_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2005.072686"},{"key":"e_1_2_5_74_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.06-0807"},{"key":"e_1_2_5_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700213"},{"key":"e_1_2_5_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01530.x"},{"key":"e_1_2_5_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb14870.x"},{"key":"e_1_2_5_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12329907"},{"key":"e_1_2_5_79_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00143.x"},{"key":"e_1_2_5_80_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V74.1.1.1"},{"key":"e_1_2_5_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131013667"},{"key":"e_1_2_5_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2011.02.013"},{"key":"e_1_2_5_83_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.7.2562"},{"key":"e_1_2_5_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04422.x"},{"key":"e_1_2_5_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1519-x"},{"key":"e_1_2_5_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12384210"},{"key":"e_1_2_5_87_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0031-6997(25)00021-3","article-title":"The molecular biology of cytochrome P450s","volume":"40","author":"Gonzalez FJ","year":"1988","journal-title":"Pharmacol Rev"},{"key":"e_1_2_5_88_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017855"},{"key":"e_1_2_5_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701236"},{"key":"e_1_2_5_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0888-7543(05)80140-5"},{"key":"e_1_2_5_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-128X(96)00171-7"},{"key":"e_1_2_5_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-351X(98)80461-8"},{"key":"e_1_2_5_93_1","doi-asserted-by":"publisher","DOI":"10.1159\/000182546"},{"key":"e_1_2_5_94_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/3.10.1873"},{"key":"e_1_2_5_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20000801)87:3<434::AID-IJC19>3.0.CO;2-G"},{"key":"e_1_2_5_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010901)92:5<1130::AID-CNCR1430>3.0.CO;2-B"},{"key":"e_1_2_5_97_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-199910000-00010"},{"key":"e_1_2_5_98_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092284"},{"key":"e_1_2_5_99_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.3.245"},{"key":"e_1_2_5_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345366"},{"key":"e_1_2_5_101_1","doi-asserted-by":"publisher","DOI":"10.1159\/000277608"},{"key":"e_1_2_5_102_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031630"},{"key":"e_1_2_5_103_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2003001000006"},{"key":"e_1_2_5_104_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.2.7818"},{"key":"e_1_2_5_105_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1645"},{"key":"e_1_2_5_106_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1330467"},{"key":"e_1_2_5_107_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-16-3-271"},{"key":"e_1_2_5_108_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082521"},{"key":"e_1_2_5_109_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39335"},{"key":"e_1_2_5_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-012-1265-x"},{"key":"e_1_2_5_111_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.76.2.524"},{"key":"e_1_2_5_112_1","first-page":"5111","article-title":"Polymorphic CAG and GGN repeat lengths in the androgen receptor gene and prostate cancer risk: a population\u2010based case\u2010control study in China","volume":"60","author":"Hsing AW","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_5_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-006-0051-z"},{"key":"e_1_2_5_114_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.10.12.1527"},{"key":"e_1_2_5_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/22.15.3181"},{"key":"e_1_2_5_116_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.4.523"},{"key":"e_1_2_5_117_1","doi-asserted-by":"publisher","DOI":"10.1177\/120347549800300103"},{"key":"e_1_2_5_118_1","doi-asserted-by":"publisher","DOI":"10.1159\/000202983"},{"key":"e_1_2_5_119_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02891.x"},{"key":"e_1_2_5_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(79)90354-6"},{"key":"e_1_2_5_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(98)00384-6"},{"key":"e_1_2_5_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(00)00279-3"},{"key":"e_1_2_5_123_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01312.x"},{"key":"e_1_2_5_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00996.x"},{"key":"e_1_2_5_125_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353581"},{"key":"e_1_2_5_126_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-961807"},{"key":"e_1_2_5_127_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.3.333"},{"key":"e_1_2_5_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701155"},{"key":"e_1_2_5_129_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-009-9729-6"},{"key":"e_1_2_5_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02078.x"},{"key":"e_1_2_5_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04299.x"},{"key":"e_1_2_5_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-007-0241-3"},{"key":"e_1_2_5_133_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm190"},{"key":"e_1_2_5_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601583"},{"key":"e_1_2_5_135_1","first-page":"145","article-title":"Keratinocyte growth factor is an important endogenous mediator of hair follicle growth, development, and differentiation. Normalization of the nu\/nu follicular differentiation defect and amelioration of chemotherapy\u2010induced alopecia","volume":"147","author":"Danilenko DM","year":"1995","journal-title":"Am J Pathol"},{"key":"e_1_2_5_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)60820-3"},{"key":"e_1_2_5_137_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08559.x"},{"key":"e_1_2_5_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2017.00016"},{"key":"e_1_2_5_139_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.3.8474"},{"key":"e_1_2_5_140_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1970.04000100029007"},{"key":"e_1_2_5_141_1","first-page":"517","article-title":"Apert's syndrome with severe acne vulgaris","volume":"69","author":"Atherton DJ","year":"1976","journal-title":"Proc R Soc Med"},{"key":"e_1_2_5_142_1","first-page":"1310","article-title":"l'acroc\u00e9phalosyndactylie","volume":"23","author":"Me A De","year":"1906","journal-title":"Bull Mem Soc Med Hop (Paris)"},{"key":"e_1_2_5_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0596-48"},{"key":"e_1_2_5_144_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.7.1229"},{"key":"e_1_2_5_145_1","first-page":"205","article-title":"Apert's syndrome (acrocephalosyndactyly) in a patient with hyperhidrosis","volume":"52","author":"Cohn MS","year":"1993","journal-title":"Cutis"},{"key":"e_1_2_5_146_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2007.00372.x"},{"key":"e_1_2_5_147_1","doi-asserted-by":"publisher","DOI":"10.1159\/000251969"},{"key":"e_1_2_5_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(68)90107-4"},{"key":"e_1_2_5_149_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620090079019"},{"key":"e_1_2_5_150_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.11.4.393"},{"key":"e_1_2_5_151_1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1001\/archderm.1976.01630300067016","article-title":"Acne in retarded boy with autosomal chromosomal abnormality","volume":"112","author":"Funderburk SJ","year":"1976","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_152_1","doi-asserted-by":"publisher","DOI":"10.4065\/72.7.611"},{"key":"e_1_2_5_153_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200009)43:9<2041::AID-ANR15>3.0.CO;2-G"},{"key":"e_1_2_5_154_1","doi-asserted-by":"publisher","DOI":"10.1086\/302866"},{"key":"e_1_2_5_155_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.5898"},{"key":"e_1_2_5_156_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2135380100"},{"key":"e_1_2_5_157_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kei178"},{"key":"e_1_2_5_158_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.8.961"},{"key":"e_1_2_5_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2015.02.012"},{"key":"e_1_2_5_160_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.2907"},{"key":"e_1_2_5_161_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12585"},{"key":"e_1_2_5_162_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-032046"},{"key":"e_1_2_5_163_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12863-015-0165-4"},{"key":"e_1_2_5_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2006.08.002"},{"key":"e_1_2_5_165_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2014.895981"},{"key":"e_1_2_5_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-015-0449-7"},{"key":"e_1_2_5_167_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0237-9"},{"key":"e_1_2_5_168_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.732"},{"key":"e_1_2_5_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2384"},{"key":"e_1_2_5_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8502"},{"key":"e_1_2_5_171_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu352"},{"key":"e_1_2_5_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9464"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T01:12:02Z","timestamp":1750295522000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,24]]},"references-count":171,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1111\/jdv.14385"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14385","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,24]]}}}