{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:09:17Z","timestamp":1792012157203,"version":"4.4.0"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swiss National Foundation","award":["310030_140616"],"award-info":[{"award-number":["310030_140616"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hidradenitis suppurativa (<jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>) is a recalcitrant chronic skin disease with poorly understood immunopathogenic mechanisms. Previous studies reported that the interleukin\u201036 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036) cytokines [<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036\u03b1, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036\u03b2, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036\u03b3 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036 receptor antagonists (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>)] are important players in the pathogenesis of psoriasis (<jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aim to determine whether the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036 cytokines are upregulated in patients with <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>. For this purpose, we analysed local expression and systemic levels of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036 cytokines in patients with <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> and compared the results to healthy donors and patients with <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Skin biopsies from healthy donors and <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PS<\/jats:styled-content> patients were analysed for expression of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036 cytokines by immunohistochemistry and semiquantitative real\u2010time <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. The enzyme\u2010linked immunosorbent assay (<jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>) was used to measure systemic levels of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036 cytokines in the serum of the three donor groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The agonists <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036\u03b1, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036\u03b2 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036\u03b3 were found to be upregulated in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> both systemically and lesionally, while the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> was not differently regulated in comparison to healthy donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that the agonistic <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036 isoforms are upregulated in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>. The relevance of the enhanced production of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036 cytokines in <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content> pathogenesis remains to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14389","type":"journal-article","created":{"date-parts":[[2017,6,11]],"date-time":"2017-06-11T06:02:42Z","timestamp":1497160962000},"page":"2091-2096","source":"Crossref","is-referenced-by-count":65,"title":["Increased expression of the interleukin\u201036 cytokines in lesions of hidradenitis suppurativa"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8260-6449","authenticated-orcid":false,"given":"R.","family":"Thomi","sequence":"first","affiliation":[{"name":"Department of Dermatology Inselspital Bern University Hospital, University of Bern Bern 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