{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:14:05Z","timestamp":1789776845075,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T00:00:00Z","timestamp":1501804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In paediatric rosacea, ocular symptoms are often predominant. Literature about systemic therapy of paediatric ocular rosacea is sparse, though.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Analysis of children with ocular rosacea treated systemically, particularly addressing remission and recurrence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study reviewing the medical records of children with ocular rosacea treated with systemic antibiotic therapy. Nine of 19 patients were chosen for detailed analysis. To our knowledge, this is the first study in paediatric ocular rosacea requiring systemic therapy with a larger patient group and a longer follow\u2010up (mean follow\u2010up = 30.2 months).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      17 patients (89.5%) suffered from blepharitis, 15 patients (78.9%) from conjunctivitis, twelve patients (63.2%) from chalazia\/styes and nine female patients (47.4%) from corneal involvement. We used erythromycin (\n                      <jats:italic>n<\/jats:italic>\n                      = 9) or roxithromycin (\n                      <jats:italic>n<\/jats:italic>\n                      = 1) in patients younger than 8 years and doxycycline (\n                      <jats:italic>n<\/jats:italic>\n                      = 8) or minocycline (\n                      <jats:italic>n<\/jats:italic>\n                      = 1) in patients older than 8 years. Seven of nine patients treated with erythromycin, one of eight patients treated with doxycycline and the patient treated with minocycline achieved a complete remission of ocular and cutaneous symptoms. Two of nine patients treated with erythromycin, seven of eight patients treated with doxycycline and the patient treated with roxithromycin achieved a partial remission. Relapses occurred in the patient treated with minocycline (cutaneous), two of eight patients treated with doxycycline (ocular and cutaneous) and one of nine patients treated with erythromycin (cutaneous).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To achieve a complete remission of cutaneous and ocular rosacea, a long\u2010term anti\u2010inflammatory treatment of at least 6 months is necessary. The relapse rates seem to be lower than in adults especially in the patients treated with erythromycin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.14402","type":"journal-article","created":{"date-parts":[[2017,6,16]],"date-time":"2017-06-16T11:56:41Z","timestamp":1497614201000},"page":"1732-1738","source":"Crossref","is-referenced-by-count":37,"title":["Systemic therapy of ocular and cutaneous rosacea in children"],"prefix":"10.1111","volume":"31","author":[{"given":"L.I.","family":"Gonser","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Gonser","sequence":"additional","affiliation":[{"name":"BG Trauma Centre University Hospital of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Deuter","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Heister","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zierhut","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University Hospital of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schaller","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.07119_supp.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200304000-00009"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30015-3"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11037.x"},{"issue":"6","key":"e_1_2_5_6_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/ddg.13139","article-title":"Pathogenesis and clinical presentation of rosacea as a key for a symptom\u2010oriented therapy","volume":"14","author":"Reinholz M","year":"2016","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000143683.14738.76"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_5_9_1","first-page":"112","article-title":"The ocular manifestations of rosacea","volume":"68","author":"Tanzi EL","year":"2001","journal-title":"Cutis"},{"key":"e_1_2_5_10_1","first-page":"99","article-title":"Rosacea in the pediatric population","volume":"74","author":"Lacz NL","year":"2004","journal-title":"Cutis"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1992.tb00320.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2006.00075.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2009.00557.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.06.047"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2007.50"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.53146"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00890-0"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12419"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.3928\/01913913-20100308-13"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31802e3a54"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000103"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090020082028"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(79)90525-7"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70255-2"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1975.tb02252.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/chorus\/v1\/articles\/10.1111%2Fjdv.14402","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T10:42:30Z","timestamp":1694947350000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,4]]},"references-count":24,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/jdv.14402"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14402","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,4]]}}}