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In this supplement, we focus on the fourth category, the iatrogenic origin of fragile skin and the role that dermo\u2010cosmetics can have in restoring the natural protective function of the skin following treatments for skin diseases and medical interventions. We present epidemiological data on the prevalence of fragile skin in three different geographical regions, and the results of two randomized controlled studies investigating the efficacy and tolerability of dermo\u2010cosmetics in combination with topical acne treatment and following physical skin damage. Overall, we found that prevalence across the three regions (23% in Germany, 41% in <jats:styled-content style=\"fixed-case\">UAE<\/jats:styled-content>, 56% in Taiwan) reflected previous global estimates (24\u201353%) across skin types, with significant associations found with environmental and lifestyle factors, such as stress, humidity and pollution. The iatrogenic effects of topical acne treatments can result in poor compliance or use of over\u2010the\u2010counter moisturizers, which may reduce treatment efficacy. Dermo\u2010cosmetics were found to aid in restoration of fragile skin caused by the acne topical retinoid treatment adapalene 0.1% gel, by reducing transepidermal water loss and improving skin hydration, as well as reducing the side\u2010effects such as skin irritation that are frequently associated with topical retinoids. Additionally, dermo\u2010cosmetic products were found to accelerate wound closure following skin damage in a laser ablation model and reduced the duration of post\u2010procedural side\u2010effects such as itching and burning.<\/jats:p>","DOI":"10.1111\/jdv.14410","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T12:45:14Z","timestamp":1502714714000},"page":"3-18","source":"Crossref","is-referenced-by-count":18,"title":["Fragility of epidermis: acne and post\u2010procedure lesional skin"],"prefix":"10.1111","volume":"31","author":[{"given":"G.","family":"Fabbrocini","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine and Surgery Section\u00a0of Dermatology University of Naples Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.B.","family":"Rossi","sequence":"additional","affiliation":[{"name":"Clinical Skin Research Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"},{"name":"Dermatology Department Toulouse University Hospital Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010D.","family":"Thouvenin","sequence":"additional","affiliation":[{"name":"Clinical Skin Research Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Peraud","sequence":"additional","affiliation":[{"name":"Clinical Skin Research Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Mengeaud","sequence":"additional","affiliation":[{"name":"Clinical Skin Research Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bacquey","sequence":"additional","affiliation":[{"name":"Clinical Skin Research Center Pierre Fabre Dermo\u2010Cosm\u00e9tique Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Saint Aroman","sequence":"additional","affiliation":[{"name":"A\u2010DERMA Pierre Fabre Dermo\u2010Cosm\u00e9tique Lavaur France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2011.08.007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12509"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13636"},{"key":"e_1_2_5_5_1","unstructured":"Blume\u2010PeytaviU ChalemY NiarraRY Le MauffA Saint AromanM.Fragility of epidermis: epidemiology study in Germany. 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