{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T15:24:30Z","timestamp":1770909870792,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relationship between atopic conditions and carcinoma of the skin has been described inconsistently. Population\u2010based data providing information on atopic diseases as well as on skin cancer are sparse.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the correlation between atopy and prevalence of precanceroses, non\u2010melanoma skin cancer and malignant melanoma (<jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>), while taking into account known risk factors for skin cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from occupational skin cancer screenings were analysed in a cross\u2010sectional study. Dermatologists performed whole body examinations and collected medical histories. Subjects comprised all employees (16\u201370 years) examined from 2006 to 2014. \u2018Atopy\u2019 was defined by clinical screening diagnosis and\/or by participant\u2010reported, pre\u2010existing atopic dermatitis, allergic asthma or other specified allergies confirmed by a physician. Tentative screening diagnoses of skin cancer related to actinic keratosis, basal cell carcinoma and malignant melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort comprised 90 265 employees (mean age 43 \u00b1 11 years, 58.5% male), 30.7% of whom were ever diagnosed with an atopic disease. Persons with atopic conditions recorded in their medical history and at the time of screening had a significantly lower prevalence of actinic keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>), basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>. After controlling for age, sex and relevant risk factors (skin type, childhood sun burns), atopy remained significantly protective against <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.77) and <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.53).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Design limitations of the study include that all findings of skin cancer were based on clinical examination only and must therefore be considered tentative diagnoses. Furthermore, owing to the cross\u2010sectional study design, causal pathways cannot be proven. However, analyses of data from such a large and general population\u2010based cohort afford valuable insights into the relationship between atopic diseases and skin cancer. They provide the grounds for prospective cohort studies to evaluate and dissect the underlying mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14456","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T05:02:40Z","timestamp":1499317360000},"page":"2083-2087","source":"Crossref","is-referenced-by-count":15,"title":["Association of atopy and tentative diagnosis of skin cancer \u2013 results from occupational skin cancer screenings"],"prefix":"10.1111","volume":"31","author":[{"given":"I.","family":"Sch\u00e4fer","sequence":"first","affiliation":[{"name":"German Center for Health Services Research in Dermatology (CVderm) Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Mohr","sequence":"additional","affiliation":[{"name":"Department of Dermatology Elbe Kliniken Buxtehude Buxtehude Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Zander","sequence":"additional","affiliation":[{"name":"German Center for Health Services Research in Dermatology (CVderm) Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"F\u00f6lster\u2010Holst","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Kiel Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Augustin","sequence":"additional","affiliation":[{"name":"German Center for Health Services Research in Dermatology (CVderm) Institute for Health Services Research in Dermatology and Nursing (IVDP) University Medical Center Hamburg\u2010Eppendorf (UKE) Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00808.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07077.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12488"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-11-0668"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/11593280-000000000-00000"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12949"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09887.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-1243"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01315.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.043"},{"key":"e_1_2_5_12_1","unstructured":"KraywinkelK BertzJ LaudiA WolfU.Epidemiologie und Fr\u00fcherkennung h\u00e4ufiger Krebserkrankungen in Deutschland.2012. 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