{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:50:49Z","timestamp":1791283849279,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,16]],"date-time":"2017-08-16T00:00:00Z","timestamp":1502841600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n \n Male genital lichen sclerosus (MGLSc) is an acquired, chronic, inflammatory skin disease that is associated with significant morbidity and squamous cell carcinoma of the penis (\n PSCC<\/jats:styled-content>\n ). However, some clinical, diagnostic and management controversies endure, including the relationship with penile intraepithelial neoplasia (Pe\n IN<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To clarify clinical presentations, diagnostic approaches, histological findings, response to treatment and the relationship with Pe\n IN<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Retrospective review of patients with a diagnosis of\n MGLS<\/jats:styled-content>\n c who attended a specialist male genital dermatoses clinic.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 301 patients were identified: 260 had isolated\n MGLS<\/jats:styled-content>\n c and 41 both\n MGLS<\/jats:styled-content>\n c and Pe\n IN<\/jats:styled-content>\n . Referrals were made from the local Urology and Andrology departments (128), primary care (89),\n GUM<\/jats:styled-content>\n (54), other dermatology departments (28) and other specialties (2). In isolated\n MGLS<\/jats:styled-content>\n c, 94.6% were diagnosed clinically with 93.5% accuracy (based on data from subsequent circumcisions). In combined\n MGLS<\/jats:styled-content>\n c\/Pe\n IN<\/jats:styled-content>\n , 85.4% were diagnosed following diagnostic biopsy and 14.6% retrospectively after circumcision. In isolated\n MGLS<\/jats:styled-content>\n c, 50% were treated topically, and 50% required surgery. In\n MGLS<\/jats:styled-content>\n c\/Pe\n IN<\/jats:styled-content>\n , 78% required surgical interventions. In isolated\n MGLS<\/jats:styled-content>\n c, 92.2% achieved resolution of symptoms, 3.5% were awaiting procedures, and 4.8% were receiving ongoing topical therapy. In\n MGLS<\/jats:styled-content>\n c\/Pe\n IN<\/jats:styled-content>\n , 90.2% achieved clearance, 2.4% were waiting surgery, and 7.3% were treated topically. Only 2.7% reported ongoing symptoms, all in patients treated surgically. None progressed to\n PSCC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n \n MGLS<\/jats:styled-content>\n c is generally a disease of the uncircumcised; the majority of cases of\n MGLS<\/jats:styled-content>\n c are accurately diagnosed clinically; suspected Pe\n IN<\/jats:styled-content>\n or\n PSCC<\/jats:styled-content>\n requires histological confirmation; circumcision histology can be non\u2010specific; most men are either cured by topical treatment with ultrapotent corticosteroid (53.1%) or by circumcision (46.9%); surgical intervention is required in most cases of concomitant\n MGLS<\/jats:styled-content>\n c and Pe\n IN<\/jats:styled-content>\n ; the majority of patients with\n MGLS<\/jats:styled-content>\n c alone or with\n MGLS<\/jats:styled-content>\n c and Pe\n IN<\/jats:styled-content>\n remit with this approach; effective management appears to negate the risk of malignant transformation to\n PSCC<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.14488","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T12:26:40Z","timestamp":1501158400000},"page":"91-95","source":"Crossref","is-referenced-by-count":83,"title":["The diagnosis and management of male genital lichen sclerosus: a retrospective review of 301 patients"],"prefix":"10.1111","volume":"32","author":[{"given":"G.","family":"Kravvas","sequence":"first","affiliation":[{"name":"Department of Dermatology University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.N.","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Dermatology University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.R.","family":"Doiron","sequence":"additional","affiliation":[{"name":"Department of Dermatology University College London Hospitals London 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