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The primary endpoints were the change in wound size 12 weeks after treatment and evaluation of adverse events. Secondary endpoints included the time to complete wound epithelialization and change in pain levels. Postoperative wound treatment modalities and treatment of comorbidities were not intensified compared with pre\u2010operative management. Follow\u2010up period was at least 6 months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen elderly ulcer patients (seven with\n                      <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content>\n                      , nine with\n                      <jats:styled-content style=\"fixed-case\">AVLU<\/jats:styled-content>\n                      ) were treated as described. All\n                      <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content>\n                      patients (median ulcer size: 48.25 cm\n                      <jats:sup>2<\/jats:sup>\n                      ) and four of nine\n                      <jats:styled-content style=\"fixed-case\">AVLU<\/jats:styled-content>\n                      patients showed complete epithelialization of the ulcers within 71\u2013174 days. In three patients with large ulcerations on both legs, ulcerations on the non\u2010treated, contralateral leg also epithelialized. Patients reported a considerable rapid decrease in pain intensity by 2.5 points on average on a visual scale from 1 to 5 within the first 2 weeks after treatment. The patients were followed up for 9\u201344 months (median: 30 months). No severe side\u2010effects were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The use of\n                      <jats:styled-content style=\"fixed-case\">SVF<\/jats:styled-content>\n                      cells presents an effective, minimally invasive option for the treatment of\n                      <jats:styled-content style=\"fixed-case\">VLU<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">AVLU<\/jats:styled-content>\n                      even in multimorbid patients. In patients with larger predominantly ischaemic\n                      <jats:styled-content style=\"fixed-case\">AVLU<\/jats:styled-content>\n                      and comorbidities, one\u2010time application of the used amounts of\n                      <jats:styled-content style=\"fixed-case\">SVF<\/jats:styled-content>\n                      cells was not sufficient in the majority of cases.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.14489","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T12:32:49Z","timestamp":1501158769000},"page":"2104-2118","source":"Crossref","is-referenced-by-count":38,"title":["Therapy of ulcus cruris of venous and mixed venous arterial origin with autologous, adult, native progenitor cells from subcutaneous adipose tissue: a prospective clinical pilot 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