{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:51:01Z","timestamp":1791283861618,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["PI14\u201001024"],"award-info":[{"award-number":["PI14\u201001024"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Cutaneous leishmaniasis (\n CL<\/jats:styled-content>\n ) is underestimated in Spain as in other European countries due to the polymorphism of its clinical manifestations and histopathological features discouraging doctors from suspecting leishmaniasis. Mucosal manifestations (\n ML<\/jats:styled-content>\n ) are misdiagnosed due to the fact that they often mimic cancer.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n Given that leishmaniasis may be masked as different granulomatous diseases in\n Leishmania infantum<\/jats:italic>\n endemic areas, the aim of this study was to verify this misdiagnosing and contributes to the improvement of\n CL<\/jats:styled-content>\n \/\n ML<\/jats:styled-content>\n diagnosis.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A retrospective study involving formalin\u2010fixed paraffin\u2010embedded tissue biopsies with histopathological features of granulomatous lesions of unknown origin (\n GLUO<\/jats:styled-content>\n ) detected in 17 patients. This study included 13 patients with\n CL<\/jats:styled-content>\n that was used as positive controls, nine patients with other confirmed diseases used as negative controls and seven patients with histological features suggestive of\n CL<\/jats:styled-content>\n or\n ML<\/jats:styled-content>\n without confirmation. Molecular analysis was blindly performed using two different\n PCR<\/jats:styled-content>\n techniques.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n PCR<\/jats:styled-content>\n detected 15\n CL<\/jats:styled-content>\n cases in which the diagnosis was neither clinically nor histologically suspected. Leishmaniasis was confirmed in seven suspected patients in whom the classical techniques failed to detect the parasite.\n L. infantum<\/jats:italic>\n was identified in all cases. A systematic review of\n CL<\/jats:styled-content>\n cases in\n GLUO<\/jats:styled-content>\n patients from European countries identified 45 reported cases.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In\n L. infantum<\/jats:italic>\n endemic areas\n ,<\/jats:italic>\n a high percentage of\n GLUO<\/jats:styled-content>\n are due to\n Leishmania<\/jats:italic>\n infection. The main consequences are delayed diagnosis and underestimation of the real incidence.\n PCR<\/jats:styled-content>\n performed on paraffin\u2010embedded tissue proved to be a reliable tool for diagnosis of\n CL<\/jats:styled-content>\n \/\n ML<\/jats:styled-content>\n and must be performed routinely in any granulomatous dermatitis, even when the morphological features are no stereotypical of leishmaniasis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.14506","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T06:38:00Z","timestamp":1501828680000},"page":"117-124","source":"Crossref","is-referenced-by-count":21,"title":["Cutaneous leishmaniasis by\n Leishmania infantum:<\/i>\n behind granulomatous lesions of unknown aetiology"],"prefix":"10.1111","volume":"32","author":[{"given":"G.","family":"Merino\u2010Espinosa","sequence":"first","affiliation":[{"name":"Department of Parasitology Faculty of Pharmacy University of Granada Granada 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