{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:16:57Z","timestamp":1791389817777,"version":"4.3.3"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,9,7]],"date-time":"2017-09-07T00:00:00Z","timestamp":1504742400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n According to the current guidelines, the aim of vulvar lichen sclerosus (\n VLS<\/jats:styled-content>\n ) treatment was to improve symptoms and signs, not to cure.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To assess (i) the rate of patients with\n VLS<\/jats:styled-content>\n who achieved complete clearance of symptoms or objective features, or both, with a 12\u2010week pharmacological treatment and (ii) the predictive value of therapeutic response to the demographic and clinical features.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We retrospectively included patients with\n VLS<\/jats:styled-content>\n who had undergone any topical treatment for 12\u00a0weeks; demographics, history,\n VLS<\/jats:styled-content>\n \u2010related symptoms and objective features recorded at baseline and on completion of treatment were collected and elaborated. The primary study endpoint was to assess the rate of patients achieving complete clearance of global subjective score (\n GSS<\/jats:styled-content>\n ), or in global objective score (\n GOS<\/jats:styled-content>\n ), and in both scores.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and ninety\u2010six patients were included; 24 (12.2%) were asymptomatic at baseline, and nine (4.6%) dropped out. After treatment, 78 patients (47.3%) achieved\n GSS<\/jats:styled-content>\n \u00a0=\u00a00, 40 (21.4%) achieved\n GOS<\/jats:styled-content>\n \u00a0=\u00a00, and 23 (13.9%) achieved complete clearance of both symptoms and signs. Lower symptom scores at baseline and shorter disease duration were associated with the achievement of symptom clearance at the end of the treatment. Earlier disease onset, diagnosis and beginning of study treatment as well as lower baseline\n GOS<\/jats:styled-content>\n were significantly associated with complete recovery of\n VLS<\/jats:styled-content>\n signs and clearance of both symptoms and signs.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n A relevant part of patients who undergo a 12\u2010week topical treatment is not completely cured of\n VLS<\/jats:styled-content>\n . It may be hypothesized that these patients, in spite of a significant improvement, may still have substantial residual disease and, as a result, its effect on their quality of life.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.14516","type":"journal-article","created":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T12:46:41Z","timestamp":1502369201000},"page":"96-101","source":"Crossref","is-referenced-by-count":15,"title":["Clearance in vulvar lichen sclerosus: a realistic treatment endpoint or a chimera?"],"prefix":"10.1111","volume":"32","author":[{"given":"A.","family":"Borghi","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Mediche Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Virgili","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Minghetti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Toni","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Corazza","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Sezione di Dermatologia e Malattie Infettive Universit\u00e0 degli Studi di Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12910"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14074"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2015.2595"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12617"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332831"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.0643"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13136"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14096"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09997.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12219"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15125"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jdv.14516","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:56:50Z","timestamp":1791280610000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,7]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/jdv.14516"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14516","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,7]]}}}