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Providing appropriate management of\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      from an early stage requires to include prompt diagnosis and treatment of concomitant diseases and to prevent any potential comorbidity. This approach should consider the adverse events of the drugs used to treat\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      potentially related to the onset of a comorbidity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To provide the dermatologist with an accurate, easily used tool that will inform the diagnosis of\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      comorbidity, and to facilitate decision\u2010making regarding the referral and treatment of patient with\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      \u2010associated comorbidity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      These recommendations have been developed by a working group composed of seven experts (three dermatologists, a cardiovascular specialist internist, a rheumatologist expert in spondyloarthritis, a gastroenterologist and a psychiatrist) and a team of three methodologist researchers. The expert group selected the\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      comorbidities considered in these recommendations through a literature review. The recommendations on diagnostic criteria are based on the relevant clinical practice guidelines for each of the comorbidities and on the recommendations of the experts. The information regarding the repercussion of\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      medical treatments on associated comorbid diseases was obtained from the summary of product characteristics of each drug.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The comorbidities considered in this guide are as follows: cardiovascular risk factors (diabetes, dyslipidaemia, obesity, hypertension and metabolic syndrome), inflammatory bowel disease, inflammatory joint disorders and psychological disorders (anxiety and depression). In addition, the association between\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      and the consumption of alcohol and tobacco is included. The tables and figures are a precise, easy\u2010to\u2010use tool to systematize the diagnosis of comorbidity in patients with\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      and facilitate the decision\u2010making process regarding referral and treatment of patients with an associated disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The application of these recommendations will facilitate the dermatologist practice and benefit\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      patients\u2019 health and quality of life.\n                    <\/jats:p>\n                  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