{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:50:53Z","timestamp":1791283853996,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T00:00:00Z","timestamp":1505174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hidradenitis suppurativa (\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      ) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels and scarring involving the intertriginous skin. Patients with\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      often report an array of systemic symptoms such as fatigue and malaise. The aetiology of these symptoms remains unclear. Previously, various bacteria have been associated with mature\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      lesions, and bacteraemia has been reported in patients with\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      using traditional culturing methods. Thus, we hypothesized that a low\u2010grade bacteraemia contributes to the symptomatology in patients with\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To explore the potential presence of bacteraemia in patients with\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      and healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A case\u2013control study. Compositions of bacteria in the blood of 27 moderate to severe\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      patients and 26 healthy controls were investigated using next\u2010generation 16S ribosomal\n                      <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                      gene sequencing (\n                      <jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content>\n                      ) and routine anaerobic and aerobic blood culturing.\n                    <\/jats:p>\n                    <jats:p>\n                      None of the participants received any antibiotics (systemic or topical therapy) within 1 month prior to the study.\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      patients with a recent flare were randomly selected by consecutive recruitment of eligible patients from the Department of Dermatology, Zealand University Hospital, Denmark. Healthy controls were recruited from the University of Copenhagen as well as from the healthcare staff.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The different bacterial compositions were investigated using\n                      <jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content>\n                      and traditional anaerobic and aerobic blood culturing. Our\n                      <jats:styled-content style=\"fixed-case\">NGS<\/jats:styled-content>\n                      analysis provided a previously unreported characterization of the bacterial composition in peripheral blood from patients with\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      and healthy controls. Overall, our data demonstrated that patients with\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      do not have a different bacterial composition in their peripheral blood than healthy controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The study suggests that the self\u2010reported symptoms in\n                      <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n                      such as malaise and fatigue may not be linked to bacteraemia.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.14538","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T02:02:45Z","timestamp":1503367365000},"page":"125-128","source":"Crossref","is-referenced-by-count":19,"title":["Moderate to severe hidradenitis suppurativa patients do not have an altered bacterial composition in peripheral blood compared to healthy controls"],"prefix":"10.1111","volume":"32","author":[{"given":"H.C.","family":"Ring","sequence":"first","affiliation":[{"name":"Department of Dermatology Zealand University Hospital Health Sciences Faculty University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Thorsen","sequence":"additional","affiliation":[{"name":"COPSAC Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.M.","family":"Saunte","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital Health Sciences Faculty University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Lilje","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Bay","sequence":"additional","affiliation":[{"name":"Costerton Biofilm Center University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Theut Riis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital Health Sciences Faculty University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Danish Genome Institute Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"O'Brien Andersen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Vedel Nielsen","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.M.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital Health Sciences Faculty University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Bjarnsholt","sequence":"additional","affiliation":[{"name":"Costerton Biofilm Center University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Fuursted","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infection Control Statens Serum Institut Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.B.","family":"Jemec","sequence":"additional","affiliation":[{"name":"Department of Dermatology Zealand University Hospital Health Sciences Faculty University of Copenhagen Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000431175"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1014163"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0866"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13025"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504370"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12793"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix285"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096194"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.0904"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12966"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09198.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2537"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-015-1596-5"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446021"}],"container-title":["Journal 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