{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:37:49Z","timestamp":1780547869108,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Frontal fibrosing alopecia (FFA) is a cicatricial alopecia that affects the frontotemporal hairline, eyebrows and body hair. <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> is a non\u2010invasive imaging technique useful in understanding skin architecture and vascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe structural and vascular findings in <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content> using <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a case\u2013control study conducted from the months of December 2016\u2013February 2017. The study was <jats:styled-content style=\"fixed-case\">IRB<\/jats:styled-content> approved and conducted at the University of Miami Hospital outpatient dermatology hair and nail clinic in Miami, <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>. Four patients with biopsy proven <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>, and three healthy age and sex\u2010matched controls participated. <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> scans were taken on cicatricial alopecic band, inflammatory hairline, eyebrow, uninvolved scalp, facial papules, glabellar red dots and arm. The same body regions were evaluated in controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients and controls were women aged 42\u201366. Results reveal epidermal thickness is increased in the inflammatory hairline (0.13\u00a0mm) and decreased in the alopecic band (0.08\u00a0mm) compared to controls (0.10\u00a0mm). Attenuation coefficient increased the inflammatory hairline and decreased in the alopecic band compared to controls. Vascular flow in the alopecic band is decreased compared to inflammatory scalp and controls in the superficial levels, but increased at deeper levels as compared to controls. Inflammatory tissue is consistently more vascular at all levels (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Vascular flows in each stage are significantly different than one another (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased vascular flow of the deep plexus in cicatricial stages can be a consequence of superficial tissue ischaemia or fibrosis. It is difficult to establish if the increased flow in the inflammatory stage is due to neovascularization as seen in other ischaemic diseases or is the result of the inflammatory response. <jats:styled-content style=\"fixed-case\">OCT<\/jats:styled-content> may be a useful non\u2010invasive tool in imaging <jats:styled-content style=\"fixed-case\">FFA<\/jats:styled-content>. Not only can the technology assist in monitoring disease activity in a non\u2010invasive manner, but it may elucidate new pathophysiologic findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14571","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T17:32:45Z","timestamp":1504200765000},"page":"318-322","source":"Crossref","is-referenced-by-count":24,"title":["Optical coherence tomography for the investigation of frontal fibrosing alopecia"],"prefix":"10.1111","volume":"32","author":[{"given":"N.E.","family":"Vazquez\u2010Herrera","sequence":"first","affiliation":[{"name":"Tecnologico de Monterrey Campus Monterrey Monterrey NL Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.E.","family":"Eber","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Martinez\u2010Velasco","sequence":"additional","affiliation":[{"name":"Universidad Nacional Autonoma de Mexico Cl\u00ednica de Oncodermatolog\u00eda Del Coyoac\u00e1n Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Perper","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cervantes","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.H.","family":"Verne","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Magno","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Nouri","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tosti","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; 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