{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:01:48Z","timestamp":1789704108243,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:00:00Z","timestamp":1508198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006526","name":"\u00d6sterreichische Gesellschaft f\u00fcr Dermatologie und Venerologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006526","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Biologics have greatly improved psoriasis management. However, primary and secondary non\u2010response to treatment requires innovative strategies to optimize outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the use of combined treatment of biologics with conventional systemic agents or phototherapy in daily clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected data on frequency of use, demographics, treatment characteristics and drug survival of biologics combined with conventional systemic agents or phototherapy in five <jats:styled-content style=\"fixed-case\">PSONET<\/jats:styled-content> registries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 9922 biologic treatment cycles, 982 (9.9%) were identified as combination treatment. 72.9% of treatment cycles concerned concomitant use of methotrexate, 25.3% concerned concomitant <jats:styled-content style=\"fixed-case\">UVB<\/jats:styled-content> therapy, acitretin or cyclosporin and 1.8% concerned combined treatment with <jats:styled-content style=\"fixed-case\">PUVA<\/jats:styled-content>, fumaric acids or a second biologic. Substantial variation was detected in type and frequency of combination treatments prescribed across registries. Patients initiated on combined treatment had generally severe disease and were affected with psoriasis for many years. The extent to which patients had been priory treated with biologic monotherapy and the proportion of patients affected with psoriatic arthritis differed between registries. Survival rates for etanercept, adalimumab, infliximab and ustekinumab with methotrexate ranged between 43 and 92%, 28 and 83%, 65 and 87% and 53 and 77%, respectively, across registries after one year with no consistent superior survival for a particular biologic. Longest survival on a biologic combined with methotrexate, acitretin or cyclosporin was 103, 78 and 34\u00a0months, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Methotrexate was the most commonly used concomitant treatment for patients on a biologic. Wide geographical variations in treatment selection and persistence of combination treatment exist. Data derived from ongoing studies may help to determine whether combined treatment is superior to biologic monotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14583","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T16:17:34Z","timestamp":1505233054000},"page":"245-253","source":"Crossref","is-referenced-by-count":35,"title":["Biologics combined with conventional systemic agents or phototherapy for the treatment of psoriasis: real\u2010life data from PSONET registries"],"prefix":"10.1111","volume":"32","author":[{"given":"C.I.","family":"Busard","sequence":"first","affiliation":[{"name":"Department of Dermatology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.D.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Quality Measurements and Research Clalit Health Services Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gkalpakiotis","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology Third Faculty of Medicine Charles University and University Hospital of Kralovske Vinohrady Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Cazzaniga","sequence":"additional","affiliation":[{"name":"Centro Studi GISED Fondazione per la Ricerca Ospedale Maggiore Bergamo Italy"},{"name":"Dermatology Department  Inselspital University Hospital Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.S.","family":"Stern","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.A.","family":"Hutten","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Biostatistics and Bioinformatics Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Feldhamer","sequence":"additional","affiliation":[{"name":"Department of Quality Measurements and Research Clalit Health Services Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Quehenberger","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics Statistics and Documentation Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lichem","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kojanova","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology Charles University First Faculty of Medicine and General University Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Adenubiova","sequence":"additional","affiliation":[{"name":"Department of Dermatovenereology Third Faculty of Medicine Charles University and University Hospital of Kralovske Vinohrady Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Addis","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Servizio Sanitario Regionale Regione Lazio Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Naldi","sequence":"additional","affiliation":[{"name":"Centro Studi GISED Fondazione per la Ricerca Ospedale Maggiore Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.I.","family":"Spuls","sequence":"additional","affiliation":[{"name":"Department of Dermatology Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09384.x"},{"key":"e_1_2_7_3_1","first-page":"737","article-title":"Burden of dose escalation with tumour necrosis factor inhibitors in rheumatoid arthritis: a systematic review of frequency and costs","volume":"33","author":"Moots RJ","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033486"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-014-0097-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.406"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.11.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(03)80164-9"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305259"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2006.099978"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2016.1118457"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12313"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206588"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.380"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.1111"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2014.3456"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11015.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0511"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10358.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.003"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12196"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000367890"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14270"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000183757"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12344"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2130"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13539"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2214"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13001"},{"key":"e_1_2_7_30_1","first-page":"e34","article-title":"Drug survival studies in dermatology: principles, purposes, and pitfalls","volume":"135","author":"Reek JM","year":"2015","journal-title":"J Invest Dermatol"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15027"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13354"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.11.007"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1586\/1744666X.2013.836060"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.10.020"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204769"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08564.x"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.208"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1777-y"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1777"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2014.941919"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T03:35:16Z","timestamp":1695008116000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,17]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/jdv.14583"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14583","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,17]]}}}