{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:53:10Z","timestamp":1771462390758,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The epidemiology of Adamantiades\u2010Beh\u00e7et's disease varies among ethnic populations worldwide. Trends in the incidence of Adamantiades\u2010Beh\u00e7et's disease have not been investigated based on the Korean National Health Insurance database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study investigated the incidence and mortality of Adamantiades\u2010Beh\u00e7et's disease by age using nationwide population data in Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nationwide population\u2010based cohort study was performed using the Korean National Health Insurance Claims Database from 2006 to 2015. The incidence of Adamantiades\u2010Beh\u00e7et's disease was calculated by age, sex, calendar year and habitat. And comorbid metabolic diseases were also analysed in patients with Adamantiades\u2010Beh\u00e7et's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The annual incidence of Adamantiades\u2010Beh\u00e7et's disease per 100\u00a0000 person\u2010years was 3.976 (2.587 for males and 5.373 for females) from 2006 to 2015. The incidence of Adamantiades\u2010Beh\u00e7et's disease peaked among people in their 40s (6.561 per 100\u00a0000 person\u2010years). Incidence was significantly higher in subjects with comorbid metabolic conditions, such as diabetes mellitus, hypertension and dyslipidemia. The mortality rate per 1000 person\u2010years increased with age in patients with Adamantiades\u2010Beh\u00e7et's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed the incidence, prevalence and mortality of Adamantiades\u2010Beh\u00e7et's disease. Metabolic conditions increased the risk of Adamantiades\u2010Beh\u00e7et's disease among Koreans.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14601","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T07:03:11Z","timestamp":1505977391000},"page":"999-1003","source":"Crossref","is-referenced-by-count":32,"title":["Incidence, prevalence, and mortality of Adamantiades\u2010Beh\u00e7et's disease in Korea: a nationwide, population\u2010based study (2006\u20132015)"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8642-2479","authenticated-orcid":false,"given":"Y.B.","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.Y.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.S.","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The Catholic University of Korea Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.W.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.D.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.G.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.S.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"S6","article-title":"Behcet's disease: an update on the pathogenesis","volume":"19","author":"Gul A","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2015.1136422"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830189709116843"},{"key":"e_1_2_6_5_1","first-page":"488","article-title":"Epidemiology of Adamantiades\u2010Behcet's disease","volume":"150","author":"Zouboulis CC","year":"1999","journal-title":"Ann Med Interne (Paris)"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(98)80001-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.151.4.2273"},{"key":"e_1_2_6_8_1","first-page":"708","article-title":"T cell responses to 60\/65\u00a0kDa heat shock protein derived peptides in Turkish patients with Behcet's disease","volume":"27","author":"Direskeneli H","year":"2000","journal-title":"J Rheumatol"},{"key":"e_1_2_6_9_1","first-page":"310","article-title":"Clinical observations on Behcet's disease in Tianjin, China","volume":"29","author":"Geng L","year":"1985","journal-title":"Jpn J Ophthalmol"},{"key":"e_1_2_6_10_1","first-page":"244","article-title":"Prevalence of Behcet's syndrome in Hawaii. 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