{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:42:51Z","timestamp":1791337371525,"version":"4.3.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:00:00Z","timestamp":1508803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Abstract<\/jats:title>Introduction<\/jats:title>Daylight PDT<\/jats:styled-content> (DLPDT<\/jats:styled-content>) is a new PDT<\/jats:styled-content> procedure. Several trials demonstrate that DLPDT<\/jats:styled-content> achieves similar response rates with conventional PDT<\/jats:styled-content> (CPDT<\/jats:styled-content>) in the treatment of non\u2010hyperkeratotic actinic keratoses (AK<\/jats:styled-content>s) in a nearly painless way. It seems that DLPDT<\/jats:styled-content> represents a more convenient and equally effective treatment modality. Data on long\u2010term efficacy of DLPDT<\/jats:styled-content> are limited.<\/jats:p><\/jats:sec>Objective<\/jats:title>To compare short\u2010 and long\u2010term efficacy, safety and tolerability of DLPDT<\/jats:styled-content> with that of CPDT<\/jats:styled-content> in face and scalp AK<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Methods<\/jats:title>The study, an intra\u2010individual right\u2013left comparison study, was conducted in three centres in North, Center and South Greece. Eligible patients received either DLPDT<\/jats:styled-content> or CPDT<\/jats:styled-content> randomly allocated to alternate sides of face or scalp. Patients were evaluated at baseline, 3 and 12\u00a0months after treatment. Assessments included lesion response at 3 and 12\u00a0months, PDT<\/jats:styled-content>\u2010associated pain during PDT<\/jats:styled-content> session, local skin reactions 3\u00a0days after treatment as well as patients\u2019 preference 3\u00a0months after treatment.<\/jats:p><\/jats:sec>Results<\/jats:title>A total of 46 patients completed the study. Three months after treatment, the overall lesion complete response rate was 78% for DLPDT<\/jats:styled-content> and 80.6% for CPDT<\/jats:styled-content>. At the 12\u2010month follow\u2010up, response rate decreased to 71.8% and 73.7% for DLPDT<\/jats:styled-content> and CPDT<\/jats:styled-content> accordingly. Regarding response based on lesion grade, response rates obtained in grade\u2010I lesions were higher with DLPDT<\/jats:styled-content>, while treatment with CPDT<\/jats:styled-content> resulted to higher rates of cured grade\u2010II<\/jats:styled-content> lesions at both follow\u2010up visits. Results were not supported by statistical significance. DLPDT<\/jats:styled-content> was associated with significantly lower pain and reduced severity of local skin reactions. Patients\u2019 preference favoured DLPDT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our study demonstrated that DLPDT<\/jats:styled-content> is similar to CPDT<\/jats:styled-content> in terms of long\u2010term efficacy and recurrence rates in the treatment of face and scalp AK<\/jats:styled-content>s. DLPDT<\/jats:styled-content> demonstrated a better tolerability profile as it was associated with lower pain and less severe adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14613","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T15:52:40Z","timestamp":1507045960000},"page":"595-600","source":"Crossref","is-referenced-by-count":52,"title":["Conventional vs. daylight photodynamic therapy for patients with actinic keratosis on face and scalp: 12\u2010month follow\u2010up results of a randomized, intra\u2010individual comparative analysis"],"prefix":"10.1111","volume":"32","author":[{"given":"E.","family":"Sotiriou","sequence":"first","affiliation":[{"name":"First Dermatology Department Medical School Aristotle University of Thessaloniki Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Evangelou","sequence":"additional","affiliation":[{"name":"Dermatology Department University Hospital of 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Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Panagiotou","sequence":"additional","affiliation":[{"name":"Second Dermatology Department National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Stefanidou","sequence":"additional","affiliation":[{"name":"Dermatology Department University Hospital of Crete Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Pombou","sequence":"additional","affiliation":[{"name":"Dermatology Department University Hospital of Crete Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Krasagakis","sequence":"additional","affiliation":[{"name":"Dermatology Department University Hospital of Crete Crete Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Rigopoulos","sequence":"additional","affiliation":[{"name":"Second 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