{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:15:41Z","timestamp":1762161341541},"reference-count":71,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mycosis fungoides (<jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>) is the major subtype of cutaneous T\u2010cell lymphomas (<jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>). It usually has a prolonged indolent clinical course with a minority of cases acquiring a more aggressive biological profile and resistance to conventional therapies, partially attributed to the persistent activation of nuclear factor\u2010kappa B (<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB) pathway. In the last decade, several papers suggested an important role for the <jats:styled-content style=\"fixed-case\">FK<\/jats:styled-content>506\u2010binding protein 51 (<jats:styled-content style=\"fixed-case\">FKBP<\/jats:styled-content>51), an immunophilin initially cloned in lymphocytes, in the control of <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB pathway in different types of human malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to investigate the possible value of <jats:styled-content style=\"fixed-case\">FKBP<\/jats:styled-content>51 expression as a new reliable marker of outcome in patients with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed by immunohistochemistry (<jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">FKBP<\/jats:styled-content>51 expression in 44 patients with <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>, representative of different stages of the disease. Immunohistochemical results were subsequently confirmed at <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> level with quantitative <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content>) in a subset of enrolled patients. In addition, <jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">qPCR<\/jats:styled-content> served to study the expression of some <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB\u2010target genes, including the tumour necrosis factor receptor\u2010associated factor 2 (TRAF2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results show that <jats:styled-content style=\"fixed-case\">FKBP<\/jats:styled-content>51 was expressed in all evaluated cases, with the highest level of expression characterizing <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content>s with the worst prognosis. Moreover, a significant correlation subsisted between <jats:styled-content style=\"fixed-case\">FKBP<\/jats:styled-content>51 and <jats:styled-content style=\"fixed-case\">TRAF<\/jats:styled-content>2 <jats:styled-content style=\"fixed-case\">IHC<\/jats:styled-content> expression scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We hypothesize a role for <jats:styled-content style=\"fixed-case\">FKBP<\/jats:styled-content>51 as a prognostic marker for <jats:styled-content style=\"fixed-case\">MF<\/jats:styled-content> and suggest an involvement of this immunophilin in deregulated <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03baB pathway of this <jats:styled-content style=\"fixed-case\">CTCL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14614","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T19:22:38Z","timestamp":1507144958000},"page":"735-744","source":"Crossref","is-referenced-by-count":7,"title":["Expression of <scp>FK<\/scp>506\u2010binding protein 51 (<scp>FKBP<\/scp>51) in Mycosis fungoides"],"prefix":"10.1111","volume":"32","author":[{"given":"M.","family":"Mascolo","sequence":"first","affiliation":[{"name":"Pathology Section Department of Advanced Biomedical Sciences University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.F.","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ilardi","sequence":"additional","affiliation":[{"name":"Pathology Section Department of Advanced Biomedical Sciences University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Medical Biotechnologies University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Baldo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Scalvenzi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Naples Federico II Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Argenziano","sequence":"additional","affiliation":[{"name":"Dermatology Unit University of Campania Luigi Vanvitelli Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Merolla","sequence":"additional","affiliation":[{"name":"Department of Medicine and Health Sciences \u201cV. 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