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The objective of this review was to present and appraise the available evidence describing the <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> cancerization field, with the aim of determining a precise definition of the <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> field in terms of its molecular (including genetic and immunological), histological and clinical characteristics. Eight European dermatologists collaborated to conduct a review and expert appraisal of articles detailing the characteristics of the <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> field. Articles published in English before August 2016 were identified using PubMed and independently selected for further assessment according to predefined preliminary inclusion and exclusion criteria. In addition, a retrospective audit of patients with <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> was performed to define the <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> field in clinical terms. A total of 32 review articles and 47 original research articles provided evidence of sun\u2010induced molecular (including genetic and immunological) and histological skin changes in the sun\u2010exposed area affected by <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>. However, the available literature was deemed insufficient to inform a clinical definition of the <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> field. During the retrospective audit, visible signs of sun damage in 40 patients with <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> were assessed. Telangiectasia, atrophy and pigmentation disorders emerged as \u2018reliable or very reliable\u2019 indicators of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> field based on expert opinion, whereas \u2018sand paper\u2019 was deemed a \u2018moderately reliable\u2019 indicator. This literature review has revealed a significant gap of evidence to inform a clinical definition of the <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> field. Therefore, the authors instead propose a clinical definition of field cancerization based on the identification of visible signs of sun damage that are reliable indicators of field cancerization based on expert opinion.<\/jats:p>","DOI":"10.1111\/jdv.14652","type":"journal-article","created":{"date-parts":[[2017,10,21]],"date-time":"2017-10-21T12:56:35Z","timestamp":1508590595000},"page":"544-563","source":"Crossref","is-referenced-by-count":81,"title":["Defining the actinic keratosis field: a literature review and discussion"],"prefix":"10.1111","volume":"32","author":[{"given":"I.","family":"Figueras Nart","sequence":"first","affiliation":[{"name":"Department of Dermatology Bellvitge Hospital Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cerio","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Medicine and Surgery The Royal London Hospital and QMUL Bart's Health NHS Trust London 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