{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:16:50Z","timestamp":1779113810035,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Until 1995, a case of psoriasis developing within the dermatome of a healed herpes zoster was taken as a Koebner phenomenon. In this year, however, the term \u2018isotopic response\u2019 was introduced by Wolf <jats:italic>et al<\/jats:italic>. to describe \u2018the occurrence of a new skin disorder at the site of another, unrelated and already healed skin disease\u2019, thus appearing \u2018on apparently unaffected and healthy skin\u2019. Initially, the term was mainly related to herpes zoster, but today the name \u2018Wolf's isotopic response\u2019 is used to include a plethora of other triggering factors such as healed cutaneous leishmaniasis, tinea or varicella. For obvious reasons, such triggering factors cannot be taken as examples of \u2018unaffected and healthy skin\u2019. Notably, the authors themselves have categorized the dermatome of a healed herpes zoster as a \u2018vulnerable area\u2019. In a recent commentary, Wolf <jats:italic>et al<\/jats:italic>. have expanded the definition of healed skin diseases triggering an \u2018isotopic response\u2019. They now included \u2018scars, pigment changes, color changes or various other minimal changes by the first disease\u2019. Hence, there is no clear\u2010cut criterion to distinguish the isotopic response from a Koebner reaction. Wolf <jats:italic>et al<\/jats:italic>. even argue that, if the triggered disorder precedes the appearance of generalized skin lesions, then it is not a Koebner reaction but \u2018Wolf's isotopic response\u2019. In our view, such definition is unacceptable. All reactions of this kind represent examples of a Koebner phenomenon. Accordingly, the \u2018isotopic response\u2019 should today be taken as a historical error.<\/jats:p>","DOI":"10.1111\/jdv.14664","type":"journal-article","created":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T11:46:41Z","timestamp":1509191201000},"page":"542-543","source":"Crossref","is-referenced-by-count":21,"title":["Koebner's sheep in Wolf's clothing: does the isotopic response exist as a distinct phenomenon?"],"prefix":"10.1111","volume":"32","author":[{"given":"R.","family":"Happle","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical Center University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kluger","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Allergology and Venereology University of Helsinki and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"210","article-title":"Ueber die Aetiologie der Psoriasis","volume":"50","author":"K\u00f6bner H","year":"1872","journal-title":"Jahresbericht der Schlesischen Gesellschaft f\u00fcr vaterl\u00e4ndische Kultur"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1990.tb03821.x"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1990.tb03808.x"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb03616.x"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1991.01680080111013"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.04.002"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2014.04.004"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2015.10.011"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620140101033"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1958.01560070016003"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1965.01600090054011"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)80063-X"},{"key":"e_1_2_2_14_1","first-page":"87","article-title":"Zosteriform lichen planus after herpes zoster","volume":"197","author":"Braun RP","year":"1998","journal-title":"Dermatology"},{"key":"e_1_2_2_15_1","first-page":"222","article-title":"Many faces of Koebner phenomenon in psoriasis","volume":"68","author":"Gupta S","year":"2002","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.09.014"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2000.00423.x"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02878.x"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01300.x"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.169133"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20164686"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000471787"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2013.05.012"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.10.046"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.009"},{"key":"e_1_2_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2017.02.003"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14664","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14664","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T11:18:47Z","timestamp":1695554327000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,22]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/jdv.14664"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14664","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,22]]}}}