{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:15:59Z","timestamp":1790630159364,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intravenous immunoglobulins (IVIG) are an attractive therapeutic tool for therapy of toxic epidermal necrolysis and severe forms of certain autoimmune diseases, including dermatomyositis, autoimmune blistering diseases, systemic vasculitis and lupus erythematodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Prompted by a case of IVIG\u2010associated haemolytic anaemia, the effects of IVIG administrations on haematological parameters in patients with dermatological conditions were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Erythrocyte and leucocyte parameters were retrospectively analysed in 16 patients who had received IVIG at doses from 1 to 3 g\/kg bodyweight (<jats:italic>n<\/jats:italic> = 35 cycles). The influence of IVIG on leucocyte survival was determined <jats:italic>in vitro<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Decreased absolute erythrocyte numbers, haemoglobin and haematocrit levels and a case of haemolytic anaemia were linked to transfusion of high\u2010, but not low\u2010dose IVIG. In contrast, leucopenia post\u2010IVIG occurred in the vast majority of the recipients, unrelated to the administered IVIG amounts. <jats:italic>In vitro<\/jats:italic> investigations revealed a dose\u2010dependent impairment of cell survival by IVIG in the neutrophil and monocyte, but not in the lymphocyte subpopulations. In several IVIG preparations, substantial amounts of blood group anti\u2010A\/anti\u2010B antibodies were detected which could have accounted for the observed changes in the haematological parameters in our study cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IVIG products should be administered strictly according to indications. Commercially available IVIG products can contain blood group\u2010specific antibodies that may induce haemolysis in some recipients. Monitoring of blood counts during applied IVIG therapy, especially when high doses are administered, is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14671","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T08:51:44Z","timestamp":1510131104000},"page":"1004-1010","source":"Crossref","is-referenced-by-count":16,"title":["Effect of intravenous immunoglobulin administration on erythrocyte and leucocyte parameters"],"prefix":"10.1111","volume":"32","author":[{"given":"A.","family":"Cicha","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.B.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Health Science and Biomedicine Danube University Krems Krems an der Donau Austria"},{"name":"Department of Transfusion Medicine Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wesinger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.M.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.M.","family":"Wolf","sequence":"additional","affiliation":[{"name":"Immunology Outpatient Clinic Vienna Austria"},{"name":"Medical School Sigmund Freud University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.T.","family":"Sauerwein","sequence":"additional","affiliation":[{"name":"Immunology Outpatient Clinic Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Reininger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Petzelbauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Pehamberger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Handisurya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra993360"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom6010015"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444700"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13725"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00011"},{"key":"e_1_2_6_7_1","unstructured":"Canadian Blood Services.Important information regarding IVIG associated hemolysis. 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