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Due to their impact and complexity, nc\n                    <jats:styled-content style=\"fixed-case\">ISD<\/jats:styled-content>\n                    represent a major challenge of modern medicine. Dermatology textbooks describe more than 100 different nc\n                    <jats:styled-content style=\"fixed-case\">ISD<\/jats:styled-content>\n                    based on clinical phenotype and histological architecture. In the last decades, this historical description was complemented by increasing molecular knowledge \u2013 and this knowledge is now being translated into specific therapeutics. Combining the enormous advances made in lymphocyte immunology and molecular genetics with clinical and histological phenotyping reveals six immune response patterns of the skin \u2013 type I immune cells cause the lichenoid pattern characterized by immune\u2010mediated cell death of keratinocytes; type\n                    <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                    immune cells underlie the eczematous pattern with impaired epidermal barrier, infection and eosinophils as well as the bullous pattern with loss of epithelial integrity; Th17 cells and\n                    <jats:styled-content style=\"fixed-case\">ILC<\/jats:styled-content>\n                    3 mediate the psoriatic pattern characterized by acanthosis, high metabolic activity and neutrophils; dysbalance of regulatory T cells causes either the fibrogenic pattern with rarefication of cells and dermal thickening or the granulomatous pattern defined by formation of granulomas. With more and more specific therapeutic agents approved, classifying nc\n                    <jats:styled-content style=\"fixed-case\">ISD<\/jats:styled-content>\n                    also according to their immune response pattern will become highly relevant. This review defines the six immune response patterns of nc\n                    <jats:styled-content style=\"fixed-case\">ISD<\/jats:styled-content>\n                    and highlights therapeutic strategies targeting key lymphocyte mediators.\n                  <\/jats:p>","DOI":"10.1111\/jdv.14673","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T03:52:39Z","timestamp":1510113159000},"page":"692-703","source":"Crossref","is-referenced-by-count":174,"title":["Immune response patterns in non\u2010communicable inflammatory skin diseases"],"prefix":"10.1111","volume":"32","author":[{"given":"K.","family":"Eyerich","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Technical University of Munich Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Eyerich","sequence":"additional","affiliation":[{"name":"ZAUM \u2013 Center of Allergy and Environment Technical University and 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