{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:11:14Z","timestamp":1787015474261,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005847","name":"Health and Medical Research Fund","doi-asserted-by":"publisher","award":["11121101"],"award-info":[{"award-number":["11121101"]}],"id":[{"id":"10.13039\/501100005847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004853","name":"Chinese University of Hong Kong","doi-asserted-by":"publisher","award":["2016.022"],"award-info":[{"award-number":["2016.022"]}],"id":[{"id":"10.13039\/501100004853","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Household cleaning products are widely used by the public, but limited data have been obtained on whether their use induces allergic dermatitis in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the association between exposure to household cleaning products and allergic dermatitis in primary\u2010school children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective cohort study of Hong Kong primary\u2010school children was conducted between 2012 and 2014. A baseline survey was administered to 1812 students who did not have allergic dermatitis. Information on respiratory symptoms, exposure to household chemical cleaning products and other topics was collected using a self\u2010administered questionnaire. A cumulative chemical burden (\n                      <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>\n                      ) score was calculated for each student by summing the duration of exposure to 14 chemical cleaning products. Principal component analysis was used to identify patterns in the use of these cleaning products. Logistic regression was performed to calculate relative risk (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      ) with 95% confidence intervals (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      s) after adjusting for potential confounders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010nine (4.9%) of the students surveyed had dermatitis during the follow\u2010up. However, exposure to individual chemical cleaning products was not found to be associated with the children's allergic dermatitis (all\n                      <jats:italic>P<\/jats:italic>\n                      &gt; 0.05). In contrast to those in the lowest tertile, neither\n                      <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>\n                      scores in the middle tertile (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      : 1.16, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.67 to 2.00) nor those in the highest tertile (\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      : 1.24, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.73 to 2.14) were significantly associated with the risk of allergic dermatitis. The adjusted\n                      <jats:styled-content style=\"fixed-case\">RR<\/jats:styled-content>\n                      for every 5\u2010unit increment in\n                      <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>\n                      score was 1.01 (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      : 0.98 to 1.03). Four patterns of cleaning\u2010product use were derived, but none were found to be associated with the risk of dermatitis (all\n                      <jats:italic>P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of household chemical cleaning products is not associated with the risk of dermatitis in primary\u2010school children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jdv.14680","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T03:52:32Z","timestamp":1510113152000},"page":"624-631","source":"Crossref","is-referenced-by-count":5,"title":["Household cleaning products and the risk of allergic dermatitis: a prospective cohort study with primary\u2010school 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