{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T21:10:37Z","timestamp":1694985037357},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Spitz naevi may present with clinical and histopathological atypical features that do not affect patient prognosis but may become worrisome for patients \u226540\u00a0years presenting with newly appearing <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Patient characteristics and sun behaviour patterns were investigated in correlation with age. <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content> characteristics and histopathological attributes were also investigated in correlation with age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with histopathologically confirmed diagnosis of <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content> were invited for a clinical examination. Data such as skin type, number of banal\/atypical naevi, sun exposure patterns and personal\/family history were collected. Histopathology preparations were re\u2010examined by two different histopathologists, and characteristics were collected based on a prespecified checklist. Patients were afterwards followed up every 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 110 patients with <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content> were identified and assigned to three age groups. The most common area of presentation was the trunk, for the \u226540\u00a0years age group, and the limbs for the other age groups. Patients \u226540\u00a0years had a higher possibility of presenting with a naevus count \u226550 and at least one atypical naevus compared to the other age groups. Patients \u226540\u00a0years presented more commonly with a history of painful sunburn (100%) before the appearance of the <jats:styled-content style=\"fixed-case\">SN<\/jats:styled-content>, used less sunscreen, had higher sun exposure times and more clinical signs of solar skin damage compared to the other age groups. Finally, patients \u226540\u00a0years presented more commonly with signs of histopathological atypia such as the presence of mitoses, cellular atypia and prominent nucleolus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients \u226540 were more likely to report a history of longer sun exposure times, of never using a sunscreen and of having a history of painful sunburn. However, the importance of this observation remains to be elucidated as these patients also presented more commonly with lesions located on non\u2010sun\u2010exposed areas (trunk) and higher naevus\/atypical naevus counts.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14702","type":"journal-article","created":{"date-parts":[[2017,11,18]],"date-time":"2017-11-18T03:36:43Z","timestamp":1510976203000},"page":"1128-1137","source":"Crossref","is-referenced-by-count":3,"title":["Patients with Spitz naevi in the Greek population: Epidemiologic, Clinical and Histopathological characteristics"],"prefix":"10.1111","volume":"32","author":[{"given":"E.","family":"Soura","sequence":"first","affiliation":[{"name":"1st University Department of Dermatology \u2013 Venereology \u201cAndreas Sygros\u201d Hospital National and Kapodistrian University of Athens Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dimitrakopoulou","sequence":"additional","affiliation":[{"name":"Department of Histopathology \u201cAndreas Sygros\u201d Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Christofidou","sequence":"additional","affiliation":[{"name":"Department of Histopathology \u201cAndreas Sygros\u201d Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Katoulis","sequence":"additional","affiliation":[{"name":"2nd Department of Dermatology and Venereology \u201cAttikon\u201d General University Hospital National and Kapodistrian University of Athens Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Antoniou","sequence":"additional","affiliation":[{"name":"1st University Department of Dermatology \u2013 Venereology \u201cAndreas Sygros\u201d Hospital National and Kapodistrian University of Athens Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Stratigos","sequence":"additional","affiliation":[{"name":"1st University Department of Dermatology \u2013 Venereology \u201cAndreas Sygros\u201d Hospital National and Kapodistrian University of Athens Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"591","article-title":"Melanomas of childhood","volume":"24","author":"Spitz S","year":"1948","journal-title":"Am J Pathol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1963.tb57111.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1001\/archderm.1973.01620250023005","article-title":"Spindle cell nevi in adults and children","volume":"108","author":"Coskey RJ","year":"1973","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197707)40:1<217::AID-CNCR2820400134>3.0.CO;2-2"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1001\/archderm.1978.01640240053018","article-title":"Nevus of large spindle and\/or epithelioid cells (Spitz's nevus)","volume":"114","author":"Paniago\u2010Pereira C","year":"1978","journal-title":"Arch Dermatol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.3.282"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0207-RA"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800519"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000185249.21805.d3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.026"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13665"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000157749.18591.9e"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.09.015"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.170"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15339"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30065-2"},{"key":"e_1_2_6_18_1","unstructured":"EnglishD MacLennanR RiversJKet\u00a0al.Epidemiological studies of melanocytic naevi: protocol for identifying and recording naevi IARC internal report Lyon: International Agency for Research on Cancer 1990."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.02.047"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800515"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90193-4"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246051"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.11.1381"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.04.040"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181934218"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e3181c52b99"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.11.037"},{"key":"e_1_2_6_28_1","first-page":"36","article-title":"The histology and differential diagnosis of Spitz nevus","volume":"10","author":"Binder SW","year":"1993","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_6_29_1","first-page":"51","article-title":"Histopathologic features of Spitzoid lesions in different age groups","volume":"54","author":"Diaconeasa A","year":"2013","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002920050304"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.06.045"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-197900140-00005"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(82)80313-7"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13467"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.03.027"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70608-9"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.09.037"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T20:57:58Z","timestamp":1694984278000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,12]]},"references-count":36,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/jdv.14702"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14702","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,12]]}}}