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Various environmental and intrinsic factors have been identified as predisposing factors for <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>, but its aetiology remains poorly understood. Although it was recognized that genetic factors play a role in <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> aetiology, there have not been studies that systematically review the literature specifically for causal mutations or protein deficiencies in <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>. In this review, we searched various databases for gene mutations and protein deficiencies that cause <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\u2010like phenotype in humans and experimental animals, and summarize 11 gene mutations or protein deficiencies that were described in the literature. Most of the encoded proteins play a role either in the immune response (<jats:styled-content style=\"fixed-case\">ACT<\/jats:styled-content>1, C5, <jats:styled-content style=\"fixed-case\">IKBKG<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NEMO<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> STK<\/jats:styled-content>4, 2C <jats:styled-content style=\"fixed-case\">TCR<\/jats:styled-content>) or epidermal differentiation (<jats:styled-content style=\"fixed-case\">ZNF<\/jats:styled-content>750, <jats:styled-content style=\"fixed-case\">MPZL<\/jats:styled-content>3). Understanding the genetic basis of <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> can impart knowledge of the pathobiology of the disease and help identify novel therapeutic targets.<\/jats:p>","DOI":"10.1111\/jdv.14704","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T08:02:59Z","timestamp":1511164979000},"page":"529-536","source":"Crossref","is-referenced-by-count":36,"title":["The genetic basis of seborrhoeic dermatitis: a review"],"prefix":"10.1111","volume":"32","author":[{"given":"M.A.","family":"Karakadze","sequence":"first","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.A.","family":"Hirt","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL 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