{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:52:57Z","timestamp":1790776377226,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,12,22]],"date-time":"2017-12-22T00:00:00Z","timestamp":1513900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Electrochemotherapy (<jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>) is currently used to treat unresectable superficial tumours of different histotypes through the combination of cytotoxic chemotherapy and local application of electric pulses. In 2006, a collaborative project defined the <jats:styled-content style=\"fixed-case\">ESOPE<\/jats:styled-content> (European Standard Operating Procedures of Electrochemotherapy) guidelines to standardize the procedure. The International Network for Sharing Practices of Electrochemotherapy (Insp<jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content>) aims to refine the <jats:styled-content style=\"fixed-case\">ESOPE<\/jats:styled-content> and improve clinical practice. Limiting patient exposure to systemic chemotherapy would be advisable to ameliorate <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> safety profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the efficacy and toxicity of <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> with reduced chemotherapy dosages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective analysis of a prospectively maintained database (Insp<jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> registry), we evaluated the outcome of patients who received <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> with reduced dosages of bleomycin (7500, 10 000 or 13 500 <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/m<jats:sup>2<\/jats:sup>, instead of the standard dose of 15 000 <jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\/m<jats:sup>2<\/jats:sup>). Tumour response in melanoma patients was compared with melanoma patients of the Insp<jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> registry who received the standard dose of bleomycin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 57 patients with 147 tumours (melanoma, 38.6%; squamous cell carcinoma, 22.8%; basal cell carcinoma, 17.5%; breast cancer 7%; Kaposi sarcoma 7%; other histotypes, 7.1%). Per\u2010tumour complete response (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) rate at 60 days was 70.1% (partial, 16.3%); per\u2010patient <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> was 57.9% (partial, 21.1%). Local pain was the most frequently reported side\u2010effect (<jats:italic>n<\/jats:italic> = 22 patients [39%]), mostly mild; two patients experienced flu\u2010like symptoms, one patient nausea. We observed the same <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> rate (55%) in patients with melanoma treated by reduced or conventional bleomycin dosages (<jats:italic>P<\/jats:italic> = 1.00).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Electrochemotherapy performed with reduced bleomycin dosages could be as effective as with currently recommended dose. Patients with impaired renal function or candidate to multiple <jats:styled-content style=\"fixed-case\">ECT<\/jats:styled-content> cycles could benefit from a reduced dose protocol. Our findings need prospective confirmation before being adopted in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14708","type":"journal-article","created":{"date-parts":[[2017,11,25]],"date-time":"2017-11-25T01:22:37Z","timestamp":1511572957000},"page":"1147-1154","source":"Crossref","is-referenced-by-count":56,"title":["Electrochemotherapy of unresectable cutaneous tumours with reduced dosages of intravenous bleomycin: analysis of 57 patients from the International Network for Sharing Practices of Electrochemotherapy registry"],"prefix":"10.1111","volume":"32","author":[{"given":"R.","family":"Rotunno","sequence":"first","affiliation":[{"name":"Dermatologic Clinic \u2018Sapienza\u2019 University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.G.","family":"Campana","sequence":"additional","affiliation":[{"name":"Department of Surgery Oncology and Gastroenterology (DISCOG) University of Padova Padova Italy"},{"name":"Veneto Institute of Oncology IOV\u2010IRCCS Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Quaglino","sequence":"additional","affiliation":[{"name":"Dermatologic Clinic Department Medical Sciences University of Turin Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"de Terlizzi","sequence":"additional","affiliation":[{"name":"Scientific &amp; Medical Department IGEA S.p.A. 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