{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:01:02Z","timestamp":1792036862194,"version":"4.4.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>More than 20 years ago, our reappraisal of the Hutchinson's sign (HS) gave birth to the concept of the pseudo\u2010Hutchinson's sign.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We have found it interesting to emphasize some important histologic points and to expand the list of the numerous HS simulants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have examined the cutaneous samples taken from the pigmented skin of patients in association with nail matrix biopsy. We have also extended the long list of non\u2010melanoma HS based on comprehensive literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histologically, HS may present only as an epidermal pigmentation, depending on the area sampled. Occasionally, there may be a sparse junctional melanocytic proliferation which does not demonstrate cytologic atypia due to an underlying melanocytic naevus of the nail matrix. However, early HS often shows a melanoma <jats:italic>in situ<\/jats:italic>, with a HS at the proximal nail fold (PNF) and confluent \u201catypical\u201d melanocytes in the nail matrix. Finally, involvement of the PNF, nail matrix and nail bed containing atypical melanocytes in irregular array may be seen in more advanced lesions. The recent literature on non\u2010melanoma HS simulants is summarized and clinical examples are provided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The mere presence of periungual pigmentation is neither clinically nor histologically pathognomonic of subungual melanoma and justifies the usefulness of this work stressing the non\u2010melanoma HS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14715","type":"journal-article","created":{"date-parts":[[2017,11,25]],"date-time":"2017-11-25T01:46:45Z","timestamp":1511574405000},"page":"495-501","source":"Crossref","is-referenced-by-count":30,"title":["Non\u2010melanoma Hutchinson's sign: a reappraisal of this important, remarkable melanoma simulant"],"prefix":"10.1111","volume":"32","author":[{"given":"L.R.","family":"Baran","sequence":"first","affiliation":[{"name":"Nail Diseases Center Cannes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.S.","family":"Ruben","sequence":"additional","affiliation":[{"name":"Department of Dermatology\/Dermatopathology University of California San Francisco CA USA"},{"name":"Department of Dermatopathology Palo Alto Medical Foundation Palo Alto CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kechijian","sequence":"additional","affiliation":[{"name":"(Retired) Manhasset NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Dermatology Centre Hospitalier Lyon Sud Pierre Benite Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"210","article-title":"Melanosis often not black; melanotic whitlow","volume":"1","author":"Hutchinson 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