{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T21:09:10Z","timestamp":1777583350828,"version":"3.51.4"},"reference-count":81,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003554","name":"Lundbeckfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether children with atopic dermatitis have an altered risk of contact allergy than children without atopic dermatitis is frequently debated and studies have been conflicting. Theoretically, the impaired skin barrier in atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) facilitates the penetration of potential allergens and several authors have highlighted the risk of underestimating and overlooking contact allergy in children with atopic dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of contact allergy in Danish children with atopic dermatitis and explore the problem of unacknowledged allergies maintaining or aggravating the skin symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional study, 100 children and adolescents aged 5\u201317\u00a0years with a diagnosis of atopic dermatitis were patch tested with a paediatric series of 31 allergens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty per cent of the children had at least one positive patch test reaction, and 17% had at least one contact allergy that was relevant to the current skin symptoms. The risk of contact allergy was significantly correlated to the severity of atopic dermatitis. Metals and components of topical skincare products were the most frequent sensitizers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patch testing is relevant as a screening tool in the management of children with atopic dermatitis as they may have unacknowledged contact allergies contributing to or maintaining their skin symptoms. Children with atopic dermatitis seem to be at greater risk of sensitization to certain allergens including metals and components of skincare products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14737","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T18:26:36Z","timestamp":1512843996000},"page":"428-436","source":"Crossref","is-referenced-by-count":40,"title":["Children with atopic dermatitis may have unacknowledged contact allergies contributing to their skin symptoms"],"prefix":"10.1111","volume":"32","author":[{"given":"A.B.","family":"Simonsen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Aarhus University Hospital Aarhus Denmark"},{"name":"National Allergy Research Centre Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Deleuran","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.G.","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital University of Copenhagen Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sommerlund","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","volume-title":"1. 7 edn","author":"Friedmann PS","year":"2004"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2012.33.3553"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra074081"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12358"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12397"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155502320624087"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03885.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2340\/0001555556135138","article-title":"Patch testing, tuberculin testing and sensitization with dinitrochlorobenzene and nitrosodimethylanilini of patients with atopic dermatitis","volume":"56","author":"Forsbeck M","year":"1976","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1973.01620170029009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670330053005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10852.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.02.001"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441548"},{"key":"e_1_2_6_15_1","first-page":"693","article-title":"Allergic contact dermatitis in children","volume":"149","author":"Fontana E","year":"2014","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e318273a3e0"},{"key":"e_1_2_6_17_1","first-page":"39","article-title":"Frequency of contact allergens in pediatric patients with atopic dermatitis","volume":"4","author":"Herro EM","year":"2011","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1995"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15628"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555924447"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247298"},{"key":"e_1_2_6_22_1","volume-title":"Manual of Contact Dermatitis","author":"Fregert S","year":"1974"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01915.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08112.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1309-62"},{"key":"e_1_2_6_27_1","first-page":"55","article-title":"Prevalence of contact allergy in children suffering from atopic dermatitis, seborrhoeic dermatitis and in healthy controls","volume":"20","author":"Silny W","year":"2013","journal-title":"Ann Agric Environ Med"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01029.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01248.x"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12436"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.04.015"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.03.012"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12219"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.445"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12873"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.030"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000154"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12568"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00693.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12492"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02001.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31826e4591"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12721"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12525"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12669"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1979.tb04857.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12711"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01890.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09708.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01860.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12711"},{"key":"e_1_2_6_52_1","first-page":"184","article-title":"Contact allergy in atopics, who perform wet work in hospital","volume":"30","author":"Lammintausta K","year":"1982","journal-title":"Derm Beruf Umwelt"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1977.tb03633.x"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1994.tb00588.x"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06032.x"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.0548d.x"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.07.066"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01898.x"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.11.007"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01602.x"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.07.015"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb04528.x"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05708.x"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01328.x"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12050"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(80)80366-5"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01250.x"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06845.x"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2010.01128.x"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12129"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04078.x"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0846-8"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01220.x"},{"key":"e_1_2_6_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1989.01670150056006"},{"key":"e_1_2_6_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12196"},{"key":"e_1_2_6_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.06.048"},{"key":"e_1_2_6_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12630"},{"key":"e_1_2_6_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1956.tb12808.x"},{"key":"e_1_2_6_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14476"},{"key":"e_1_2_6_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01943.x"},{"key":"e_1_2_6_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01669.x"},{"key":"e_1_2_6_82_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1996.d01-1096.x"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14737","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14737","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:04:33Z","timestamp":1695549873000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,3]]},"references-count":81,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/jdv.14737"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14737","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,3]]}}}