{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:52:43Z","timestamp":1790790763240,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Identification of myositis\u2010specific autoantibodies (<jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>s) for dermatomyositis (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>) could allow the characterization of an antibody\u2010associated clinical phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We sought to define the clinical phenotype of <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> and the risk of cancer, interstitial lung disease (<jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>) and calcinosis based on <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A 3.5\u2010year multicentre prospective study of adult <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients was conducted to determine the clinical phenotype associated with <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>s and the presence of cancer, <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> and calcinosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>s were detected in 47.1% of 117 included patients. Patients with antimelanoma differentiation\u2010associated protein\u20105 antibodies (13.7%) had significantly more palmar violaceous macules\/papules [odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 9.9], mechanic's hands (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 8), cutaneous necrosis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.2), articular involvement (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 15.2) and a higher risk of <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 25.3). Patients with antitranscriptional intermediary factor\u20101 antibodies (11.1%), antinuclear matrix protein\u20102 antibodies (6.8%) and antiaminoacyl\u2010transfer <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> synthetase (5.1%) had, respectively, significantly more poikiloderma (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 5.9), calcinosis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 9.8) and articular involvement (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 15.2). Cutaneous necrosis was the only clinical manifestation significantly associated with cancer (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Recognition of the adult <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> phenotype associated with <jats:styled-content style=\"fixed-case\">MSA<\/jats:styled-content>s would allow more accurate appraisal of the risk of cancer, <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> and calcinosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14759","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T18:32:38Z","timestamp":1513189958000},"page":"1164-1172","source":"Crossref","is-referenced-by-count":38,"title":["Distinctive cutaneous and systemic features associated with specific antimyositis antibodies in adults with dermatomyositis: a prospective multicentric study of 117 patients"],"prefix":"10.1111","volume":"32","author":[{"given":"M.","family":"Best","sequence":"first","affiliation":[{"name":"Department of Dermatology Saint\u2010Eloi Hospital and Montpellier University Hospital Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jachiet","sequence":"additional","affiliation":[{"name":"Department of Dermatology AP\u2010HP University of Paris VII Sorbonne Paris City and Saint\u2010Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Molinari","sequence":"additional","affiliation":[{"name":"Department of Statistics Montpellier University Hospital Montpellier France"},{"name":"IMAG, CNRS University of Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Manna","sequence":"additional","affiliation":[{"name":"Department of Statistics Montpellier University Hospital Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Girard","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint\u2010Eloi Hospital and Montpellier University Hospital Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Pallure","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Dermatology Perpignan Hospital Perpignan France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cosnes","sequence":"additional","affiliation":[{"name":"Department of Dermatology Henri\u2010Mondor Hospital Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lipsker","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Strasbourg and Dermatologic Clinic Strasbourg University Hospital Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hubiche","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Infectious Diseases Fr\u00e9jus Hospital Fr\u00e9jus France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010L.","family":"Schmutz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Brabois Hospital Nancy University Hospital Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Le Corre","sequence":"additional","affiliation":[{"name":"Department of Dermatology Angers University Hospital Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Cordel","sequence":"additional","affiliation":[{"name":"Unit of Dermatology and Internal Medicine Guadeloupe University Hospital Pointe\u2010\u00e0\u2010Pitre, Guadeloupe France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Dandurand","sequence":"additional","affiliation":[{"name":"Department of Dermatology Caremeau Hospital N\u00eemes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Dereure","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint\u2010Eloi Hospital and Montpellier University Hospital Montpellier France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1058 Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Guillot","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint\u2010Eloi Hospital and Montpellier University Hospital Montpellier France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1058 Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Du\u2010Thanh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint\u2010Eloi Hospital and Montpellier University Hospital Montpellier France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1058 Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bulai Livideanu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Toulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Chasset","sequence":"additional","affiliation":[{"name":"AP\u2010HP Department of Dermatology and Allergology Faculty of Medicine Tenon Hospital Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010D.","family":"Bouaziz","sequence":"additional","affiliation":[{"name":"Department of Dermatology AP\u2010HP University of Paris VII Sorbonne Paris City and Saint\u2010Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Franc\u00e8s","sequence":"additional","affiliation":[{"name":"AP\u2010HP Department of Dermatology and Allergology Faculty of Medicine Tenon Hospital Sorbonne University Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bengoufa","sequence":"additional","affiliation":[{"name":"Department of Immunology Saint\u2010Louis Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Immunology Saint Eloi Hospital and Montpellier University Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bessis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint\u2010Eloi Hospital and Montpellier University Hospital Montpellier France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) U1058 Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Study Group of Systemic Diseases in Dermatology (EMSED: \u00c9tude des Maladies Syst\u00e9miques en Dermatologie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05157-0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202063260602"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10794"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.134"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.10416"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21023"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22164"},{"key":"e_1_2_6_9_1","first-page":"s139","article-title":"Clinical and serological characterisation of the anti\u2010MJ antibody in childhood myositis","volume":"40","author":"Oddis C","year":"1997","journal-title":"Arthritis Rheum"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.52"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.09.016"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.12.009"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23210"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21992"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154285"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23188"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200697"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.09.013"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.097162"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01262.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155502753600894"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.09.004"},{"key":"e_1_2_6_23_1","first-page":"1012","article-title":"Clinical evaluation of anti\u2010aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis","volume":"34","author":"Matsushita T","year":"2007","journal-title":"J Rheumatol"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740802687455"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24621"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq153"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-223"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep375"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq149"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e3181ca14ff"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3547"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker518"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200871"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3822"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2012.07.019"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4207"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(07)04"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21985"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-012-0663-4"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.38093"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.755958"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201736"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/290797"},{"key":"e_1_2_6_44_1","first-page":"891","article-title":"Prevalence and clinical significance of anti\u2010MDA5 antibodies in European patients with polymyositis\/dermatomyositis","volume":"32","author":"Ceribelli A","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.011"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22498"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kev247"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-2935-9"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22728"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002863"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3453-0"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13319"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502132920706"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197502202920807"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.10.041"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0154746"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21728"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00240-6"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel161"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.1429"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.068502"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32833f1075"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.33379"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes033"},{"key":"e_1_2_6_65_1","doi-asserted-by":"publisher","DOI":"10.3109\/14397595.2015.1091155"},{"key":"e_1_2_6_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.03.004"},{"key":"e_1_2_6_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916930600622884"},{"key":"e_1_2_6_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-016-3494-3"},{"key":"e_1_2_6_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15020"},{"key":"e_1_2_6_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22862"},{"key":"e_1_2_6_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03540-6"},{"key":"e_1_2_6_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12564"},{"key":"e_1_2_6_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094128"}],"container-title":["Journal of the European Academy of Dermatology and Venereology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjdv.14759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jdv.14759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T20:58:27Z","timestamp":1694984307000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jdv.14759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,31]]},"references-count":72,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/jdv.14759"],"URL":"https:\/\/doi.org\/10.1111\/jdv.14759","archive":["Portico"],"relation":{},"ISSN":["0926-9959","1468-3083"],"issn-type":[{"value":"0926-9959","type":"print"},{"value":"1468-3083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,31]]}}}