{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:24:12Z","timestamp":1792787052351,"version":"4.5.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:00:00Z","timestamp":1516147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Amorepacific Research","award":["2013"],"award-info":[{"award-number":["2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Alopecia areata (\n AA<\/jats:styled-content>\n ) is an organ\u2010specific autoimmune disease with T\u2010cell\u2010mediated attack of hair follicle autoantigens. As T helper 17 (Th17) cells and T regulatory (Treg) cells are crucially involved in the pathogenesis, the role of Th17 and Treg cytokines has not been studied yet.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To determine whether\n AA<\/jats:styled-content>\n is associated with alterations in lesional and serum Th17 and Treg cytokines and studied whether they were associated with clinical type.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Scalp skin samples from 45 patients and eight normal controls were obtained for\n PCR<\/jats:styled-content>\n specific for\n IFN<\/jats:styled-content>\n \u2010\u03b3,\n TNF<\/jats:styled-content>\n \u2010\u03b1,\n TGF<\/jats:styled-content>\n \u2010\u03b2,\n IL<\/jats:styled-content>\n \u20101,\n IL<\/jats:styled-content>\n \u20102,\n IL<\/jats:styled-content>\n \u20104,\n IL<\/jats:styled-content>\n \u201010,\n IL<\/jats:styled-content>\n \u201012A,\n IL<\/jats:styled-content>\n \u201013,\n IL<\/jats:styled-content>\n \u201017,\n IL<\/jats:styled-content>\n \u201022 and\n IL<\/jats:styled-content>\n \u201023. Serum cytokines were measured from 55 patients and 15 normal controls using\n ELISA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Lesional\n IL<\/jats:styled-content>\n \u201017 and\n IL<\/jats:styled-content>\n \u201022 were significantly increased in patient group. Moreover, positive correlations were shown between lesional\n IL<\/jats:styled-content>\n \u201017,\n IL<\/jats:styled-content>\n \u201022 and disease severity. Serum\n IL<\/jats:styled-content>\n \u20101,\n IL<\/jats:styled-content>\n \u201017,\n TNF<\/jats:styled-content>\n \u2010\u03b1 and\n TGF<\/jats:styled-content>\n \u2010\u03b2 were significantly increased, and positive correlation was shown between serum\n IL<\/jats:styled-content>\n \u201017 and disease severity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These results showed significantly high Th17 cytokines in both lesion and serum in\n AA<\/jats:styled-content>\n patients, which may highlight a functional role of these cytokines in the pathogenesis of\n AA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jdv.14775","type":"journal-article","created":{"date-parts":[[2017,12,28]],"date-time":"2017-12-28T09:38:43Z","timestamp":1514453923000},"page":"1028-1033","source":"Crossref","is-referenced-by-count":78,"title":["Role of T helper 17 cells and T regulatory cells in alopecia areata: comparison of lesion and serum cytokine between controls and patients"],"prefix":"10.1111","volume":"32","author":[{"given":"S.\u2010H.","family":"Loh","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.\u2010N.","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Biochemical Science Graduate School Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.\u2010L.","family":"Lew","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.\u2010Y.","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Dermatology College of Medicine Kyung Hee University Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.103909"},{"key":"e_1_2_6_3_1","first-page":"69","article-title":"Alopecia areata: a tissue specific autoimmune disease of the hair follicle","volume":"5","author":"Gilar A","year":"2006","journal-title":"Autoimmun Rev"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12396"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03356.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02321.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.1.61"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2340\/0001555576421423","article-title":"Cytokines in alopecia areata: contrasting cytokine profiles in localized form and extensive 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