{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:12:48Z","timestamp":1790125968575,"version":"4.0.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically \u2018false\u2010positive\u2019 and \u2018false\u2010negative\u2019 tumours do exist. False\u2010positive diagnosis usually leads to unnecessary excisions. False\u2010negative diagnosis is much more dangerous, as it might result in overlooking a cancer, with severe undesirable consequences for the patient and the physician. Therefore, management strategies should mainly focus on addressing the risk of dermoscopically false\u2010negative tumours. The most frequent benign tumours that might acquire dermatoscopic characteristics suggestive of malignancy are seborrhoeic keratosis (SK), including solar lentigo, melanoacanthoma, irritated, clonal and regressive SK, angioma (mainly thrombosed angioma and angiokeratoma), dermatofibroma, benign adnexal tumours and naevi (Clark, Spitz, recurrent, combined, sclerosing). The most useful clues to recognize these tumours are the following: solar lentigo \u2013 broad network; melanoacanthoma \u2013 sharp border; irritated SK \u2013 regularly distributed white perivascular halos; clonal SK \u2013 classic SK criteria; regressive SK \u2013 remnants of SK; targetoid haemosiderotic haemangioma \u2013 dark centre and reddish periphery; thrombosed angioma \u2013 sharp demarcation; angiokeratoma \u2013 dark lacunae; atypical dermatofibromas \u2013 palpation; follicular tumours \u2013 white colour; sebaceous tumours \u2013 yellow colour; Clark naevi \u2013 clinical context; Spitz\/Reed naevi \u2013 age; combined naevi \u2013 blue central area; recurrent naevi \u2013 pigmentation within the scar; sclerosing naevi \u2013 age and location on the upper back; blue naevi \u2013 history. Malignant tumours that might mimic benign ones and escape detection are melanoma (\n                    <jats:italic>in\u00a0situ<\/jats:italic>\n                    , nevoid, spitzoid, verrucous, regressive, amelanotic), squamous cell carcinoma (mainly well\u2010differentiated variants) and rarely basal cell carcinoma (non\u2010pigmented variants). The most useful clues to recognize the peculiar melanoma subtypes are as follows: melanoma\n                    <jats:italic>in\u00a0situ<\/jats:italic>\n                    \u2013 irregular hyperpigmented areas; nevoid melanoma \u2013 history of growth; spitzoid melanoma \u2013 age; verrucous melanoma \u2013 blue\u2010black sign; regressive melanoma \u2013 peppering or scar\u2010like depigmentation; amelanotic melanoma \u2013 pink colour, linear irregular vessels, dotted vessels. In this article, we summarized the most frequent dermoscopic variations of common skin tumours that are often misinterpreted, aiming to assist clinicians to reduce the number of false diagnoses.\n                  <\/jats:p>","DOI":"10.1111\/jdv.14782","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T17:20:05Z","timestamp":1515518405000},"page":"879-888","source":"Crossref","is-referenced-by-count":80,"title":["The limitations of dermoscopy: false\u2010positive and false\u2010negative tumours"],"prefix":"10.1111","volume":"32","author":[{"given":"V.","family":"Papageorgiou","sequence":"first","affiliation":[{"name":"First Department of Dermatology Aristotle University Thessaloniki Greece"},{"name":"Cosmetic Derma Medicine Medical Group Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Apalla","sequence":"additional","affiliation":[{"name":"First Department of Dermatology Aristotle University Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sotiriou","sequence":"additional","affiliation":[{"name":"First Department of Dermatology Aristotle University Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Papageorgiou","sequence":"additional","affiliation":[{"name":"First Department of Dermatology Aristotle University Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Lazaridou","sequence":"additional","affiliation":[{"name":"First Department of Dermatology Aristotle University Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vakirlis","sequence":"additional","affiliation":[{"name":"First Department of Dermatology Aristotle University Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ioannides","sequence":"additional","affiliation":[{"name":"First 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