{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:52:36Z","timestamp":1785509556464,"version":"3.56.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4 and was first approved in Japan for the treatment of adult T\u2010cell leukaemia\/lymphoma (ATLL), followed by cutaneous T\u2010cell lymphoma and peripheral T\u2010cell lymphoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T\u2010cell neoplasms after treatment with Mog.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We treated seven cutaneous lymphoma patients with Mog. Upon combination treatment with narrow\u2010band UVB, we noticed that four patients developed photosensitivity dermatitis following Mog therapy, including two cases of mycosis fungoides, one case of adult T\u2010cell leukaemia\/lymphoma and one case of EB virus\u2010associated T\u2010cell lymphoproliferative disorder. Phototest was performed with UVA and UVB, and immunohistochemical staining for CD4, CD8 and Foxp3 was conducted in both photosensitivity and lymphoma lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Phototest revealed that the action spectrum of the photosensitivity was UVB in three cases and both UVB and UVA in one case. Histopathologically, the photosensitive lesions were characterized by a lichenoid tissue reaction with a CD8<jats:sup>+<\/jats:sup> T cell\u2010dominant infiltrate, sharing the feature with chronic actinic dermatitis, an autoreactive photodermatosis with a cytotoxic T\u2010cell response. Foxp3<jats:sup>+<\/jats:sup> regulatory T cells (Tregs) were decreased in the photosensitivity lesions compared with the lymphoma lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased incidence of photosensitivity reaction was observed during Mog treatment. Decreased number of Tregs in the lesional skin suggests that this reaction is possibly induced by autoreactive cytotoxic T cells.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14797","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T00:02:42Z","timestamp":1516147362000},"page":"1456-1460","source":"Crossref","is-referenced-by-count":23,"title":["Mogamulizumab\u2010induced photosensitivity in patients with mycosis fungoides and other T\u2010cell neoplasms"],"prefix":"10.1111","volume":"32","author":[{"given":"Y.","family":"Masuda","sequence":"first","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tatsuno","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hamamatsu University School of Medicine Hamamatsu 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