{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:39:07Z","timestamp":1768433947729,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:00:00Z","timestamp":1517529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008271","name":"LEO Pharma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acad Dermatol Venereol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Ingenol mebutate (IngMeb) 0.015% gel is an approved field treatment option for non\u2010hyperkeratotic non\u2010hypertrophic actinic keratosis (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>) of face and scalp. Efficacy of IngMeb has been assessed only on a clinical ground, in the majority of studies. Dermoscopy is a pivotal tool for the diagnosis of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>, while its role in evaluating the response to non\u2010surgical therapies for <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> has not been fully defined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our study aims to determine whether some dermoscopic features of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> of the face and scalp areas may independently predict the response to IngMeb therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and dermoscopic responses, 1 month after 0.015% IngMeb therapy, were retrospectively evaluated using a per\u2010patient and per\u2010lesion approach. Safety was evaluated through local skin reaction composite score calculation. Demographic, clinical and dermoscopic factors were then evaluated via univariate and multivariate logistic regression analysis to assess independent predictors of response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010five patients with 245 <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s were enrolled. Clinically, per\u2010patient response evaluation identified 25 (45.4%) poor\/partial and 30 (54.5%) complete responders, corresponding on a per\u2010lesion approach to 66 (26.9%) and 179 (73.1%) <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s, respectively. Dermoscopy reclassified 14 patients in the per\u2010patient and 48 <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s in the per\u2010lesion analysis from complete to poor\/partial responders. Multivariate logistic regression analysis showed that <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>s dermoscopically characterized by red pseudonetwork and located on the face were independently associated with a complete dermoscopic response to 0.015% IngMeb therapy, while microerosions were negative predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Specific dermoscopic features of <jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content> may predict the response to 0.015% IngMeb therapy, together with the location on the face.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jdv.14803","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T15:25:34Z","timestamp":1516634734000},"page":"1461-1468","source":"Crossref","is-referenced-by-count":9,"title":["Tracking actinic keratosis of face and scalp treated with 0.015% ingenol mebutate to identify clinical and dermoscopic predictors of treatment response"],"prefix":"10.1111","volume":"32","author":[{"given":"R.","family":"Pampena","sequence":"first","affiliation":[{"name":"Dermatology and Skin Cancer Unit First Medical Department Arcispedale Santa Maria Nuova IRCCS Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Benati","sequence":"additional","affiliation":[{"name":"Dermatology and Skin Cancer Unit First Medical Department Arcispedale Santa Maria Nuova IRCCS Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Borsari","sequence":"additional","affiliation":[{"name":"Dermatology and Skin Cancer Unit First Medical Department Arcispedale Santa Maria Nuova IRCCS Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Bombonato","sequence":"additional","affiliation":[{"name":"Dermatology and Skin Cancer Unit First Medical Department Arcispedale Santa Maria Nuova IRCCS Reggio Emilia 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